Ceenu

Drug Description

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DRUG DESCRIPTION

WARNINGS

CeeNU® (lomustine) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.

Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to bleeding and overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of CeeNU (see WARNINGSand ADVERSE REACTIONS).

Since the major toxicity is delayed bone marrow suppression, blood counts should be monitored weekly for at least 6 weeks after a dose (see ADVERSE REACTIONS). At the recommended dosage, courses of CeeNU should not be given more frequently than every 6 weeks.

The bone marrow toxicity of CeeNU is cumulative and therefore dosage adjustment must be considered on the basis of nadir blood counts from prior dose (see Dosage Adjustment Table under DOSAGE AND ADMINISTRATION ).

CeeNU® (lomustine [CCNU]) Capsules is one of the nitrosoureas used in the treatment of certain neoplastic diseases. It is 1-(2-chloro-ethyl)-3-cyclohexyl-1-nitrosourea. It is a yellow powder with the empirical formula of C ₉H ₁₆CIN ₃O ₂and a molecular weight of 233.71. CeeNU is soluble in 10% ethanol (0.05 mg per mL) and in absolute alcohol (70 mg per mL). CeeNU is relatively insoluble in water (<0.05 mg per mL).

It is relatively unionized at a physiological pH.

Inactive ingredients in CeeNU capsules are: magnesium stearate and mannitol.

CeeNU is available in 10 mg, 40 mg, and 100 mg capsules for oral administration.

Brand Name: Ceenu
Generic Name: Lomustine

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