Carbocaine

Cosmetic Dentistry Slideshow

Drug Description

font size

Carbocaine® 3% injection
(mepivacaine hydrochloride) Injection, USP

Carbocaine® 2%
with Neo-Cobefrin® 1:20,000 injection
(mepivacaine hydrochloride and levonordefrin) Injection, USP

DRUG DESCRIPTION

CARBOCAINE (mepivacaine hydrochloride), a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula:

CARBOCAINE (mepivacaine hydrochloride) Structural Formula Illustration

It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis.

NEO-COBEFRIN, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solution, is (-)-α -(1-Aminoethyl)-3, 4-dihydroxybenzyl alcohol with the following structural formula

It is a white or buff-colored crystalline solid, freely soluble in aqueous solutions of mineral acids, but practically insoluble in water.

DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED.

CARBOCAINE 3% injection and CARBOCAINE 2% with NEO-COBEFRIN 1:20,000 injection are sterile solutions for injection.

COMPOSITION:	CARTRIDGE
Each mL contains:	2%	3%
Mepivacaine hydrochloride	20mg	30mg
Levonordefrin	0.05mg	-
Sodium chloride	4mg	6mg
Potassium metabisulfite	1.2mg	-
Edetate disodium	0.25mg	-
Sodium hydroxide q.s. ad pH
Hydrochloric acid	0.5mg	-
Water for injections qs. ad.	1mL	1mL
The pH of the 2% cartridge solution is adjusted between 3.3 and 5.5 with NaOH. The pH of the 3% cartridge solution is adjusted between 4.5 and 6.8 with NaOH.