Patients taking TOPAMAX® should be told to seek immediate medical attention if they experience blurred vision or periorbital pain.

Patients, especially pediatric patients, treated with TOPAMAX® should be monitored closely for evidence of decreased sweating and increased body temperature, especially in hot weather.

Patients, particularly those with predisposing factors, should be instructed to maintain an adequate fluid intake in order to minimize the risk of renal stone formation [see PRECAUTIONS: Kidney Stones, for support regarding hydration as a preventative measure].

Patients should be warned about the potential for somnolence, dizziness, confusion, and difficulty concentrating and advised not to drive or operate machinery until they have gained sufficient experience on topiramate to gauge whether it adversely affects their mental and/or motor performance.

Additional food intake may be considered if the patient is losing weight while on this medication.

Please refer to the end of the product labeling for important information on how to take TOPAMAX® (topiramate capsules) Sprinkle Capsules.

Laboratory Tests

Measurement of baseline and periodic serum bicarbonate during topiramate treatment is recommended (see WARNINGS).

HOW TO TAKE TOPAMAX® (topiramate capsules) SPRINKLE CAPSULES

A Guide for Patients and Their Caregivers

Your doctor has given you a prescription for TOPAMAX® (topiramate capsules) Sprinkle Capsules. Here are your instructions for taking this medication. Please read these instructions prior to use.

To Take With Food

You may sprinkle the contents of TOPAMAX® Sprinkle Capsules on a small amount (teaspoon) of soft food, such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt.

Hold the capsule upright so that you can read the word “TOP.”

Carefully twist off the clear portion of the capsule. You may find it best to do this over the small portion of the food onto which you will be pouring the sprinkles.

Sprinkle all of the capsule's contents onto a spoonful of soft food, taking care to see that the entire prescribed dosage is sprinkled onto the food.

Be sure the patient swallows the entire spoonful of the sprinkle/food mixture immediately. Chewing should be avoided. It may be helpful to have the patient drink fluids immediately in order to make sure all of the mixture is swallowed. IMPORTANT: Never store any sprinkle/food mixture for use at a later time.

To Take Without Food

TOPAMAX® Sprinkle Capsules may also be swallowed as whole capsules.

For more information about TOPAMAX® Sprinkle Capsules, ask your doctor or pharmacist.

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