Moduretic
DRUG DESCRIPTION
TABLETS MODURETIC® (AMILORIDE HCL-HYDROCHLOROTHIAZIDE)
MODURETIC (Amiloride HCl-Hydrochlorothiazide) combines the potassium-conserving action of amiloride HCl with the natriuretic action of hydrochlorothiazide.
Amiloride HCl is designated chemically as 3,5-diamino-6-chloro-N-(diaminomethylene) pyrazinecarboxamide monohydrochloride, dihydrate and has a molecular weight of 302.12. Its empirical formula is C6H8ClN7O † HCl † 2H2O and its structural formula is:
Hydrochlorothiazide is designated chemically as 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and its structural formula is:
It is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.
MODURETIC is available for oral use as tablets containing 5 mg of anhydrous amiloride HCl and 50 mg of hydrochlorothiazide. Each tablet contains the following inactive ingredients: calcium phosphate, FD&C Yellow 6, guar gum, lactose, magnesium stearate and starch.
Generic Name: Amiloride and Hydrochlorothiazide
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Moduretic
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