Targretin

Drug Description

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DRUG DESCRIPTION

Targretin ^® capsules are a member of the retinoid class of drugs that is associated with birth defects in humans. Targretin ^® capsules also caused birth defects when administered orally to pregnant rats. Targretin ^® capsules must not be administered to a pregnant woman. See CONTRAINDICATIONS.

Targretin ® (bexarotene) is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Each soft gelatin capsule for oral administration contains 75 mg of bexarotene.

The chemical name is 4-[1-(5,6,7,8 -tetrahydro- 3,5,5,8,8-pentamethyl -2-naphthalenyl) ethenyl] benzoic acid, and the structual formula is as follows:

Bexarotene is an off-white to white powder with a molecular weight of 348.48 and a molecular formula of C₂₄H₂₈O₂. It is insoluble in water and slightly soluble in vegetable oils and ethanol, USP.

Each Targretin ® (bexarotene) capsule also contains the following inactive ingredients: polyethylene glycol 400, NF, polysorbate 20, NF, povidone, USP, and butylated hydroxyanisole, NF. The capsule shell contains gelatin, NF, sorbitol special-glycerin blend, and titanium dioxide, USP.

Brand Name: Targretin
Generic Name: Bexarotene

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