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Cefizox

Clinical Pharmacology
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CLINICAL PHARMACOLOGY

Cefizox

The table below demonstrates the serum levels and duration of Cefizox (ceftizoxime for injection, USP) following IM administration of 500 mg and 1 gram doses, respectively, to normal volunteers.
 

Serum Concentrations After Intramuscular Administration Serum Concentration (mcg/mL)

Dose

1/ 2hr

1 hr

2hr

4hr

6hr

8hr

500mg

13.3

13.7

9.2

4.8

1.9

0.7

1 gm

36.0

39.0

31.0

15.0

6.0

3.0


Following IV administration of 1,2, and 3 gram doses of Cefizox to normal volunteers, the following serum levels were obtained.
 

Serum Concentrations After Intra Serum Concentration venous Adm (mcg/mL) inistration

Dose

5 min

10 min

30 min

1 hr

2 hr

4 hr

8 hr 

1 gram

ND

ND 

60.5

38.9 

21.5

8.4

1.4 

2grams

131.8

110.9

77.5

53.6 

33.1

12.1

2.0

3grams

221.1

Brand Name: Cefizox
Generic Name: Ceftizoxime

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