Diovan HCT
Diovan HCT®
(valsartan and hydrochlorothiazide, USP) 80 mg/12.5 mg, 160 mg/12.5 mg, 160
mg/25 mg, 320 mg/12.5 mg, 320 mg/25 mg Combination Tablets
USE IN PREGNANCY
When used in pregnancy, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus<. When pregnancy is detected, Diovan HCT should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.
DRUG DESCRIPTION
Diovan HCT
The drug Diovan HCT is used to treat high blood pressure (hypertension). This medication is a combination of two drugs (an angiotensin receptor blocker and a thiazide "water pill"/diuretic). Valsartan blocks the hormone angiotensin thereby relaxing blood vessels, causing them to widen. The thiazide diuretic increases the amount of urine you make, therefore decreasing excess water and salt in your body. High blood pressure reduction helps prevent strokes, heart attacks, and kidney problems.
Diovan HCT® (valsartan and hydrochlorothiazide, USP) is a combination of valsartan, an orally active, specific angiotensin II antagonist acting on the AT1 receptor subtype, and hydrochlorothiazide, a diuretic.
Valsartan, a nonpeptide molecule, is chemically described as N-(1-oxopentyl)-N- [[2´-(1H-tetrazol-5-yl)[1,1´-biphenyl]-4-yl]methyl]-L-Valine. Its empirical formula is C24H29N5O3, its molecular weight is 435.5, and its structural formula is
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Valsartan is a white to practically white fine powder. It is soluble in ethanol and methanol and slightly soluble in water.
Hydrochlorothiazide USP is a white, or practically white, practically odorless, crystalline powder. It is slightly soluble in water; freely soluble in sodium hydroxide solution, in n-butylamine, and in dimethylformamide; sparingly soluble in methanol; and insoluble in ether, in chloroform, and in dilute mineral acids. Hydrochlorothiazide is chemically described as 6-chloro-3,4-dihydro-2H-1,2,4- benzothiadiazine-7- sulfonamide 1,1-dioxide. Hydrochlorothiazide is a thiazide diuretic. Its empirical formula is C7H8ClN3O4S2, its molecular weight is 297.73, and its structural formula is
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Diovan HCT tablets are formulated for oral administration to contain valsartan and hydrochlorothiazide, USP 80/12.5 mg, 160/12.5 mg, 160/25 mg, 320/12.5 mg and 320/25 mg. The inactive ingredients of the tablets are colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, iron oxides, magnesium stearate, microcrystalline cellulose, polyethylene glycol, talc, and titanium dioxide.
Generic Name: Valsartan and Hydrochlorothiazide
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Diovan HCT
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