EPINEPHRINE

The most valuable drug for the emergency treatment of severe allergic reactions is epinephrine. The vasoconstrictor effect of epinephrine on the capillary directly antagonizes the generalized vasodilation produced by histamine. Epinephrine reverses the increased permeability of dilated capillaries to plasma. The shock of severe allergic reactions is due to the loss of circulating blood volume by pooling in the dilated capillary beds and loss of plasma into the tissues. Epinephrine quickly restores circulating blood volume and blood pressure by constricting the capillary bed. The itching during episodes of hives or angioedema is promptly relieved by epinephrine. Epinephrine is a powerful relaxer of the smooth muscle of the bronchioles, stomach, intestine, pregnant uterus and urinary bladder wall. The bronchospasm, wheezing and dyspnea of the acute allergic reactions are relieved. Where abdominal cramping, defecation or involuntary urination have occurred during severe allergic attacks, epinephrine rapidly produces relief. Subcutaneously or intramuscularly administered epinephrine has a rapid onset and short duration of action. Subcutaneous administration during asthmatic attacks may produce bronchodilation within 5 to 10 minutes, and maximal effects may occur within 20 minutes.

CHLO-AMINE®

Chlo-Amine® is an effective agent in nullifying the characteristic effects of histamine and is especially valuable in the prophylaxis and relief of many allergic symptoms. It is readily absorbed from the intestinal tract and released into the tissues from the bloodstream. This action is both prompt and sustained. Elimination of the drug is such that there is a low incidence of side effects.

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