Nystatin and Triamcinolone Acetonide Cream for dermatologic use contains the antifungal agent nystatin and the synthetic corticosteroid triamcinolone acetonide.

Nystatin is a polyene antimycotic obtained from Streptomyces noursei. It is a yellow to light tan powder with a cereal-like odor, very slightly soluble in water, and slightly to sparingly soluble in alcohol. Structural formula:

Triamcinolone acetonide is designated chemically as 9-fluoro-11ß,16α, 17, 21-tetrahydroxypregna -1, 4-diene-3,20-dione cyclic 16,17-acetal with acetone. The white to cream crystalline powder has a slight odor, is practically insoluble in water, and very soluble in alcohol. Structural formula:

Nystatin and Triamcinolone Acetonide Cream provides in each gram 100,000 units nystatin and 1 mg triamcinolone acetonide in an aqueous, perfumed vanishing cream base, containing aluminum hydroxide concentrated wet gel, titanium dioxide, glyceryl monostearate, polyethylene glycol monostearate, simethicone emulsion, sorbic acid, propylene glycol, white petrolatum, cetearyl alcohol (and) ceteareth 20, and sorbitol solution.

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