Pronestyl
DRUG DESCRIPTION
| WARNING The prolonged administration of procainamide often leads to the development of a positive anti-nuclear antibody (ANA) test, with or without symptoms of a lupus erythematosus-like syndrome. If a positive ANA titer develops, the benefits versus risks of continued procainamide therapy should be assessed. |
Procainamide hydrochloride, a Group 1A cardiac antiarrhythmic drug, is p-amino-N-[2-(diethylamino)ethyl]-benzamide monohydrochloride. It differs from procaine which is the p-aminobenzoyl ester of 2-(diethylamino)-ethanol. Procainamide as the free base has a pKa of 9.23; the monohydrochloride is very soluble in water. It is available as a sterile, aqueous solution for intramuscular or intravenous use providing 100 mg or 500 mg procainamide hydrochloride per mL. The 100 mg/mL concentration contains in each mL procainamide hydrochloride 100 mg, benzyl alcohol 0.009 mL and sodium metabisulfite 0.9 mg in Water for Injection. The 500 mg/mL concentration contains in each mL procainamide hydrochloride 500 mg, benzyl alcohol 0.009 mL and sodium metabisulfite 2 mg in Water for Injection. For both concentrations, pH is 4.0-6.0; sodium hydroxide and/or hydrochloric acid added, if needed, for pH adjustment.
It has the following molecular formula C13H21N3O HCl with a molecular weight of 271.79.
Generic Name: Procainamide
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