Adenoscan
INDICATIONS
Intravenous Adenoscan is indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately (see WARNINGS).
DOSAGE AND ADMINISTRATION
For intravenous infusion only.
Adenoscan should be given as a continuous peripheral intravenous infusion.
The recommended intravenous dose for adults is 140 mcg/kg/min infused for six minutes (total dose of 0.84 mg/kg).
The required dose of thallium-201 should be injected at the midpoint of the Adenoscan infusion (i.e., after the first three minutes of Adenoscan). Thallium-201 is physically compatible with Adenoscan and may be injected directly into the Adenoscan infusion set.
The injection should be as close to the venous access as possible to prevent and inadvertent increase in the dose of Adenoscan (the contents of the IV tubing) being administered.
There are no data on the safety or efficacy of alternative Adenoscan infusion protocols.
The safety and efficacy of Adenoscan administered by the intracoronary route have not been established.
The following Adenoscan infusion nomogram may be used to determine that appropriate infusion rate corrected for total body weight:
| Patient Weight | Infusion Rate | |
| kg | lbs | mL/min |
| 45 | 99 | 2.1 |
| 50 | 110 | 2.3 |
| 55 | 121 | 2.6 |
| 60 | 132 | 2.8 |
| 65 | 143 | 3 |
| 70 | 154 | 3.3 |
| 75 | 165 | 3.5 |
| 80 | 176 | 3.8 |
| 85 | 187 | 4 |
| 90 | 198 | 4.2 |
This nomogram was derived from the following general formula:
| 0.140 (mg/kg/min) x total body weight (kg) | |
| ------------------------------------------- | - Infusion rate (ml/mL |
| Adenoscan concentration (3 mg/mL) |
Note: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.
HOW SUPPLIED
Adenoscan (adenosine injection) is supplied as 20 mL and 30 mL vials of sterile nonpyrogenic solution in normal saline.
| Product Code | NDC No. | |
| 87120 | 0469-0871-20 | 60 mg/20 mL (3 mg/mL) in a 20 mL single-dose, flip-top glass vial, packaged individually and in packages of ten. |
| 87130 | 0469-0871-30 | 90 mg/30 mL (3 mg/mL) in a 30 mL single-dose, flip-top glass vial, packaged individually and in packages of ten. |
Store at controlled room temperature 15°-30°C (59°-86°F)
Do not refrigerate as crystallization may occur. If crystallization has occurred, dissolve crystals by warming at room temperature. The solution must be clear at the time of use.
Contains no preservative. Discard unused portion.
Rx only
Marketed by: Astellas Pharma US, Inc.
Deerfield, IL 60015
Manufactured by: Hospira, Inc.
Lake Forest, IL 60045 USA
Revised: April 2005
FDA rev date: 7/14/05
Generic Name: Adenosine Inj
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Adenoscan
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