Aldoril
Aldoril® (methyldopa-hydrochlorothiazide) tablets
This fixed combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not static, but must be re-evaluated as conditions in each patient warrant.
DRUG DESCRIPTION
ALDORIL* (Methyldopa-Hydrochlorothiazide) combines two antihypertensives: methyldopa and hydrochlorothiazide.
Methyldopa
Methyldopa is an antihypertensive and is the L-isomer of alphamethyldopa. It is levo-3-(3,4-dihydroxyphenyl)-2- methylalanine. Its empirical formula is C10H13NO4, with a molecular weight of 211.22, and its structural formula is:
Methyldopa is a white to yellowish white, odorless fine powder, and is soluble in water.
Hydrochlorothiazide
Hydrochlorothiazide is a diuretic and antihypertensive. It is the 3,4-dihydro derivative of chlorothiazide. Its chemical name is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7- sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and its structural formula is:
Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.
ALDORIL is supplied as tablets in four strengths for oral use:
ALDORIL 15, contains 250 mg of methyldopa and 15 mg of hydrochlorothiazide.
ALDORIL 25, contains 250 mg of methyldopa and 25 mg of hydrochlorothiazide.
ALDORIL D30, contains 500 mg of methyldopa and 30 mg of hydrochlorothiazide.
ALDORIL D50, contains 500 mg of methyldopa and 50 mg of hydrochlorothiazide.
Each tablet contains the following inactive ingredients: calcium disodium edetate, calcium phosphate, cellulose, citric acid, colloidal silicon dioxide, ethylcellulose, guar gum, hydroxypropyl methylcellulose, magnesium stearate, propylene glycol, talc, and titanium dioxide. ALDORIL 15 and ALDORIL D30 also contain iron oxide.
Generic Name: Methyldopa-Hydrochlorothiazide
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Aldoril
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