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CHIBROXIN® (Merck)
(norfloxacin ophthalmic solution)
Sterile Ophthalmic Solution

CHIBROXIN^* (norfloxacin ophthalmic solution) is a synthetic broad-spectrum antibacterial agent supplied as a sterile isotonic solution for topical ophthalmic use. Norfloxacin, a fluoroquinolone, is 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl) -3- quinoline-carboxylic acid. Its empirical formula is C ₁₆ H ₁₈ FN ₃ O ₃ and the structural formula is:

Norfloxacin is a white to pale yellow crystalline powder with a molecular weight of 319.34 and a melting point of about 221°C. It is freely soluble in glacial acetic acid and very slightly soluble in ethanol, methanol and water.

CHIBROXIN (norfloxacin) Ophthalmic Solution 0.3% is supplied as a sterile isotonic solution. Each mL contains 3 mg norfloxacin. Inactive ingredients: disodium edetate, sodium acetate, sodium chloride, hydrochloric acid (to adjust pH) and water for injection, Benzalkonium chloride 0.0025% is added as preservative. The pH of CHIBROXIN (norfloxacin) is approximately 5.2 and the osmolarity is approximately 285 m0smol/liter.

Norfloxacin, a fluoroquinolone, differs from quinolones by having a fluorine atom at the 6 position and a piperazine moiety at the 7 position.

^*Registered trademark of MERCK & CO., INC.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.