Chibroxin
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Chibroxin
Please Note: This Brand Name drug is no longer available in the US.(Generic versions may still be available.)
DRUG DESCRIPTION
CHIBROXIN® (Merck)
(norfloxacin ophthalmic solution)
Sterile Ophthalmic Solution
CHIBROXIN* (norfloxacin ophthalmic solution) is a synthetic broad-spectrum antibacterial agent supplied as a sterile isotonic solution for topical ophthalmic use. Norfloxacin, a fluoroquinolone, is 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl) -3- quinoline-carboxylic acid. Its empirical formula is C 16 H 18 FN 3 O 3 and the structural formula is:
Norfloxacin is a white to pale yellow crystalline powder with a molecular weight of 319.34 and a melting point of about 221°C. It is freely soluble in glacial acetic acid and very slightly soluble in ethanol, methanol and water.
CHIBROXIN (norfloxacin) Ophthalmic Solution 0.3% is supplied as a sterile isotonic solution. Each mL contains 3 mg norfloxacin. Inactive ingredients: disodium edetate, sodium acetate, sodium chloride, hydrochloric acid (to adjust pH) and water for injection, Benzalkonium chloride 0.0025% is added as preservative. The pH of CHIBROXIN (norfloxacin) is approximately 5.2 and the osmolarity is approximately 285 m0smol/liter.
Norfloxacin, a fluoroquinolone, differs from quinolones by having a fluorine atom at the 6 position and a piperazine moiety at the 7 position.
*Registered trademark of MERCK & CO., INC.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Chibroxin Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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