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ChiRhoStim Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/14/2016

ChiRhoStim (Human Secretin) Injection is a gastrointestinal peptide hormone used for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction; stimulation of gastrin secretion to aid in the diagnosis of gastrinoma; and facilitation of the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP). Common side effects of ChiRhoStim include:L

  • nausea or vomiting
  • flushing
  • abdominal pain
  • increased heart rate
  • stomach upset
  • anxiety
  • warm or burning feeling in stomach or abdomen
  • clammy skin
  • diarrhea
  • faintness
  • low blood pressure
  • drowsiness, and
  • tingling in legs

The dose of ChiRhoStim for stimulation of pancreatic secretions is 0.2 mcg/kg body weight by intravenous injection over 1 minute. ChiRhoStim may interact with anticholinergic drugs. Tell your doctor all medications and supplements you use. During pregnancy, ChiRhoStim should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding. /p>

Our ChiRhoStim (Human Secretin) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

ChiRhoStim FDA Prescribing Information: Side Effects
(Adverse Reactions)


Mild to moderate adverse reactions have been noted  for synthetic human secretin in clinical studies in 533 patients   and 51 healthy volunteers. Two severe adverse reactions, nausea   and abdominal pain, occurred in one patient. Table 1 details   the type and number of patients with adverse reactions.


Adverse Reaction N = 584
Nausea 11(11)
Flushing 4 (4)
Early removal of Dreiling tube 3 (3)
Abdominal pain 3 (3)
Vomiting 3 (3)
Increased heart rate 2 (2)
Mild Pancreatitis 2 (2)
Upset stomach 2 (2)
Anxiety 1 (1)
Burning in stomach or abdomen 1 (1)
Clammy skin 1 (1)
Decreased O2 saturation 1 (1)
Diarrhea 1 (1)
Faintness 1 (1)
Hypotension 1 (1)
Infiltrated IV 1 (1)
Oral secretions increased 1 (1)
Sedation 1 (1)
Slow heart rate (57 bpm) 1 (1)
Tingling in legs 1 (1)
Unresponsive 1 (1)
Warm sensation in abdomen 1 (1)
Warm sensation in face 1 (1)

Of the 584 patients and healthy volunteers treated with ChiRhoStim® (human secretin) , a total of 29 patients (5%) had at least one adverse reaction.

Read the entire FDA prescribing information for ChiRhoStim (Human Secretin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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