"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).
Orkambi is a fixed-dose oral combination "...
(Generic versions may still be available.)
Chloramphenicol is a broad-spectrum antibiotic originally isolated from Streptomyces venezuelae. It is primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes.
Chloramphenicol has been shown to be active against the following organisms:
streptococci, including Streptococcus pneumoniae
Aerobic gram-negative microorganisms:
Moraxella lucunata (Morax-Axenfeld bacillus)
This product does not provide adequate coverage against Pseudomonas aeruginosa or Serratia marcescens.
Bacteriological studies should be performed to determine the causative organisms and their susceptibilities to chloramphenicol.
Last reviewed on RxList: 1/2/2005
This monograph has been modified to include the generic and brand name in many instances.
Additional Chloroptic Information
- Chloroptic Drug Interactions Center: chloramphenicol opht
- Chloroptic Side Effects Center
- Chloroptic Overview including Precautions
- Chloroptic FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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