May 1, 2017
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"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).

Orkambi is a fixed-dose oral combination "...



Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)



Chloramphenicol is a broad-spectrum antibiotic originally isolated from Streptomyces venezuelae. It is primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes.

Chloramphenicol has been shown to be active against the following organisms:

Aerobic gram-positive microorganisms

Staphylococcus aureus

streptococci, including Streptococcus pneumoniae

Aerobic gram-negative microorganisms:

Enterobacter sp.

Escherichia coli

Haemophilus influenzae

Klebsiella sp.

Moraxella lucunata (Morax-Axenfeld bacillus)

Nesseria sp.

This product does not provide adequate coverage against Pseudomonas aeruginosa or Serratia marcescens.

Bacteriological studies should be performed to determine the causative organisms and their susceptibilities to chloramphenicol.

Last reviewed on RxList: 1/2/2005
This monograph has been modified to include the generic and brand name in many instances.

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