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Cholera Vaccine

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Cholera Vaccine

Indications
Dosage
How Supplied

INDICATIONS

Active immunization against cholera is indicated only for individuals traveling to or residing in countries where cholera is endemic or epidemic.

DOSAGE AND ADMINISTRATION

Shake vial vigorously before withdrawing each dose.

Parenteral drug products should be inspected visually for presence of particulate matter and discoloration prior to use.

The primary immunizing course consists of two doses administered one week to one month or more apart. The table below summarizes the recommended doses for both primary and booster immunizations by age, volume (mL), and route of administration. 3,5 The intracutaneous (intradermal) route is satisfactory for persons 5 years of age and older, but higher levels of antibody may be achieved in children less than 5 years old by the subcutaneous or intramuscular routes.

 

  Route & Age
Dose number Intradermal Subcutaneous or Intramuscular
  5 years
and over
6 mos-
4 years
5-10
years
Over
10 years
1 & 2 0.2 mL 0.2 mL 0.3 mL 0.5 mL
Boosters 0.2 mL 0.2 mL 0.3 mL 0.5 mL

In areas where cholera is epidemic or endemic, booster doses should be given every six months.

The primary immunizing series need never be repeated for booster doses to be effective.

Before injection, the rubber diaphragm of the vial and the skin over the site to be injected should be cleansed and prepared with a suitable germicide.

HOW SUPPLIED

Cholera Vaccine, USP, is supplied as 1.5 and 20 mL vials.

STORAGE

Keep between 2° and 8°C (35° and 46°F).

Keep from freezing.

 

REFERENCES

  1. Recommendation of the Immunization Practices Advisory Committee (ACIP). General recommendations on immunization. MMWR 32(1):1, 1983.
  2. Recommendations of the Immunization Practices Advisory Committee (ACIP). Yellow fever vaccine. MMWR 32(52):679, 1984.
  3. Recommendation of the Public Health Service Advisory Committee on Immunization Practices--Cholera Vaccine. MMWR 27(20):173, 1978.
  4. GANGAROSA, E. and FAICH, G.: Cholera: The risk to American travelers. Ann. Int. Med. 74:412, 1971.
  5. Report of the Committee on Infectious Diseases, American Academy of Pediatrics, 1982 (Red Book).

 

Manufactured by:
Wyeth Laboratories
A Wyeth-Ayerst Company
Marietta, PA 17547

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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