Chorionic Villus Sampling (CVS)
Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
John P. Cunha, DO, FACOEP
John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.
What is chorionic villus sampling (CVS)?
Chorionic villus sampling (CVS) is a type of prenatal diagnostic test to detect chromosomal problems that can result in genetic diseases and birth defects. It involves taking a small sample of part of the placenta (the chorionic villi) where it is attached to the wall of the uterus.
CVS can diagnose chromosomal abnormalities that cause conditions like Down syndrome, sickle cell anemia, cystic fibrosis, and Tay Sachs disease. It does not diagnose neural tube defects. Since the procedure examines genetic material, it can tell you the gender of the fetus.
CVS is performed earlier in pregnancy than amniocentesis. It is done between the 10th and 13th week of pregnancy (measured from your last menstrual period). It is reported to be 98% to 99% accurate in detecting genetic abnormalities. CVS can also be used to detect paternity and is 99% accurate in establishing paternity of a fetus.
How is CVS performed?
Samples for CVS are taken in one of two ways:
- Transabdominal: In this method, similar to amniocentesis, a long, thin needle is inserted through the abdominal wall into the placenta, guided by ultrasound images.
- Transcervical: With the transcervical method, a long, thin tube is passed into the vagina and up into the uterus to obtain the sample by suction. This method is most common.
The procedure can be completed in about half an hour. The actual sampling process only takes a few minutes. There may be mild discomfort when the sample is taken. After the test you may have mild cramping and bleeding, and you should rest the day of the procedure. You may be asked to abstain from sex and vigorous activity for a few days after the test. You should contact your doctor if you experience fever, heavy vaginal bleeding or cramping, or leakage of fluid from the vagina after the test.
After the sample is removed, the cells are cultured in a laboratory and analyzed. It typically takes 7 to 10 days before results are available.
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