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See also How To Use section for drug-food interactions.

This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur: nitrates (e.g., nitroglycerin, isosorbide), nitroprusside (or any "nitric oxide donor" drugs), recreational drugs called "poppers" containing amyl or butyl nitrite.

If you are currently using any of these medications, tell your doctor or pharmacist before starting tadalafil.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alpha-blocker medication (e.g., doxazosin, prazosin, terazosin), drugs that affect certain liver enzymes (CYP 3A4 substrates, inhibitors and inducers such as cimetidine, rifamycins, St. John's wort, or certain anti-seizure drugs), high blood pressure medicines, other medications for impotence.

Do not take this medication with any other product that contains tadalafil or other similar medications used to treat erectile dysfunction/pulmonary hypertension (e.g., sildenafil, vardenafil).

If you are also taking certain drugs (potent inhibitors of CYP3A4 such as fosamprenavir, amprenavir, ritonavir, nelfinavir, erythromycin, ketoconazole, itraconazole), you must place special limits on your use of tadalafil to reduce the risk of severe dizziness. If you are taking tadalafil as needed, do not take more than one 10-milligram dose of tadalafil in a 72-hour period. If you are taking tadalafil once a day, do not take more than 2.5 milligrams a day. Contact your doctor or pharmacist for more details.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

NOTES: Do not share this medication with others, since they may have a problem that is not effectively treated by this drug, or they may have a condition that is complicated by this drug.

MISSED DOSE: If you are taking this medication on a regular schedule and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59 and 86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2010 Copyright(c) 2010 First DataBank, Inc.