Cialis

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Cialis

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Cialis (tadalafil)

Pharmacy Author: Pharmacy Editor: Jay W. Marks, MD Drug Class: phosphodiesterase type 5 (PDE5) inhibitor Similar Drugs: Adcirca (tadalafil), Levitra (vardenafil), Revatio (sildenafil), Viagra (sildenafil), Staxyn ODT (vardenafil)
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Cialis (tadalafil) Indications

Cialis has the following indications:

 

Dosage and Administration of Cialis (tadalafil)

Cialis is a selective phosphodiesterase type 5 (PDE5) inhibitor available as 2.5, 5, 10, or 20 mg tablets for oral administration

Erectile Dysfunction (used as needed)

  • For most patients the recommended starting dose is 10 mg as needed prior to anticipated sexual activity.
  • The dose may be increased to 20 mg or decreased to 5 mg based on efficacy or tolerability.
  • The maximum dosing frequency is once daily for most patients. Cialis is effective for up to 36 hours.
  • Renal dysfunction:
    • Creatinine clearance 30 to 50 ml/min: The recommended starting dose is 5 mg no more than once daily, and the maximum dose is 10 mg every 48 hours.
    • Creatinine clearance less than 30 ml/min or on hemodialysis: The maximum dose is 5 mg every 72 hours.
  • Hepatic dysfunction:
    • Mild or moderate dysfunction: Use has not been extensively evaluated. Do not exceed 10 mg daily.
    • Severe dysfunction: Use is not recommended.

Erectile Dysfunction (used daily without regard to sexual activity)

  • The recommended dose for scheduled once daily use is 2.5 mg taken at approximately the same time daily without regard to timing of sexual activity.
  • The dose may be increased to 5 mg daily based on efficacy and tolerability.
  • For patients with renal dysfunction:
    • Creatinine clearance less than 30 ml/min or on hemodialysis: Cialis is not recommended for scheduled once daily use.
  • Hepatic dysfunction:
    • Mild or moderate dysfunction: Use has not been extensively evaluated. Therefore, use with caution.
    • Severe dysfunction: Use is not recommended.

Benign prostatic hyperplasia

  • The recommended dose is 5 mg taken at approximately the same time every day.
  • Renal dysfunction:
    • Creatinine clearance 30 to 50 ml/min: Start with 2.5 mg and increase to 5 mg daily as needed and tolerated.
    • Creatinine clearance less than 30 ml/min or on hemodialysis: Cialis is not recommended for scheduled once daily use.

Combined Erectile Dysfunction and Benign prostatic hyperplasia

  • The recommended dose is 5 mg at approximately the same time every day without regard to sexual activity.
  • For patients with renal dysfunction:
    • Creatinine clearance 30 to 50 ml/min: Start with 2.5 mg and increase to 5 mg daily as needed and tolerated.
    • Creatinine clearance less than 30 ml/min or on hemodialysis: Cialis is not recommended for scheduled once daily use.
  • Hepatic dysfunction:
    • Mild or moderate dysfunction: Use has not been extensively evaluated. Therefore, use with caution.
    • Severe dysfunction: Use is not recommended.

Use with CYP3A4 inhibitors (see drug interactions)

  • Maximum dose is 10 mg every 72 hours as needed or 2.5 mg daily without regard to timing of sexual activity.
 

Contraindications, Warnings, and Precautions

Contraindications

  • Use of nitrates (for example, nitroglycerine, isosorbide): Cialis may increase hypotensive effects of nitrates.
  • Hypersensitivity reactions to tadalafil (Cialis or Adcirca)

Warnings and Precautions

  • Angina: Patients with angina should not use Cialis because sexual activity may precipitate angina.
  • Use of scheduled daily Cialis in combination with nitrates, alpha blockers, antihypertensives, and potent CYP3A4 inhibitors.
  • Prolonged erections and priapism
  • Sudden loss of vision: NAION (non-arteritic anterior ischemic optic neuropathy)
  • Sudden hearing loss.
  • Alpha blockers and antihypertensives: Cialis potentiates the antihypertensive effects of alpha blockers and antihypertensives.
  • Renal impairment: See dosing section.
  • Hepatic impairment: See dosing section.
  • Alcohol: Cialis potentiates the vasodilatory action of alcohol. Combining Cialis with substantial consumption of alcohol may result in orthostatic hypotension.
  • CYP3A4 inhibitors (for example, ritonavir, ketoconazole, itraconazole): Limit dose. (See drug interactions.)
  • Other PDE5 inhibitors: Cialis should not be combined with other PDE5 inhibitors.
  • Bleeding: PDE5 is found on platelets. Use of Cialis in patients with bleeding disorders or active peptic ulcers should be based on careful risk-benefit assessment and caution.
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Cialis - User Reviews

Cialis User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Cialis sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.




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