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IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

CERTOLIZUMAB - INJECTION

(SER-toe-LIZ-oo-mab)

COMMON BRAND NAME(S): Cimzia

WARNING: This medication can decrease your body's ability to fight an infection. This effect can lead to very serious (possibly fatal) infections (e.g., fungal infections, tuberculosis). You should have a tuberculosis (TB) skin test before starting this medication. Also tell your doctor your medical history, especially of past/recent/current infections. You should also tell your doctor if you have lived or traveled in areas where certain fungal infections (e.g., coccidioidomycosis, histoplasmosis) are common or if you have been near someone with tuberculosis. See Side Effects section for symptoms of infections to watch out for, and seek immediate medical attention if you develop any of these symptoms.

If you are diagnosed with TB, you must first be treated for it before you start certolizumab to prevent a serious TB infection.

Though it is very unlikely to happen, there is a risk (especially in children/teens/young adults) of developing cancer (such as lymphoma, skin) due to this medication or due to your medical condition. Discuss the risks and benefits of treatment with your doctor. Tell your doctor immediately if you develop symptoms such as unusual lumps/growths, swollen glands, swollen or painful abdomen, unexplained weight loss, persistent fever or night sweats.

USES: This medication is used to treat a bowel condition called Crohn's disease when it has not improved with other drugs. This medication is also used to reduce pain and swelling due to rheumatoid arthritis. Certolizumab belongs to a class of drugs known as tumor necrosis factor (TNF) blockers. It works by blocking TNF, a substance made by the body that causes swelling (inflammation).

HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using certolizumab and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

This medication is given by injection under the skin, in the stomach or thigh area, as directed by your doctor. Each dose is given as 2 separate injections. The first 3 doses are given every 2 weeks. After the third dose, if you are using this medication for Crohn's disease, it is usually given every 4 weeks or as directed by your doctor. After the third dose, if you are using this medication for rheumatoid arthritis, it is given every 2 or every 4 weeks as directed by your doctor. Follow your doctor's directions very carefully.

Remove this medication from the refrigerator and leave at room temperature for 30 minutes before injecting. Do not warm up this medication in any other way such as heating in the microwave or placing in hot water.

Do not inject into any areas of skin that are sore, bruised, red, scaly, or hard.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Use this medication regularly to get the most benefit from it. To help you remember, mark the days on a calendar when you need to receive the medication.

Tell your doctor if your condition persists or worsens.