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In this Article

• What is complement C1 esterase inhibitor (Cinryze)?
• What are the possible side effects of complement C1 esterase inhibitor (Cinryze)?
• What is the most important information I should know about complement C1 esterase inhibitor (Cinryze)?
• What should I discuss with my health care provider before using complement C1 esterase inhibitor (Cinryze)?
• How should I use complement C1 esterase inhibitor (Cinryze)?
• What happens if I miss a dose (Cinryze)?
• What happens if I overdose (Cinryze)?
• What should I avoid while using complement C1 esterase inhibitor (Cinryze)?
• What other drugs will affect complement C1 esterase inhibitor (Cinryze)?
• Where can I get more information?

What should I discuss with my health care provider before using complement C1 esterase inhibitor (Cinryze)?

You should not use this medication if you have ever had an allergic reaction to it, or if you have ever had any other life-threatening allergic reaction.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using complement C1 esterase inhibitor, tell your doctor if you have a history of stroke or blood clot.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before using complement C1 esterase inhibitor, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether complement C1 esterase inhibitor passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Complement C1 esterase inhibitor is made from human plasma (part of the blood) and may contain viruses and other infectious agents that can cause disease. Although donated human plasma is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Do not give this medication to a child, even if you think the child has the same condition you have.

How should I use complement C1 esterase inhibitor (Cinryze)?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Complement C1 esterase inhibitor is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Complement C1 esterase inhibitor is usually given every 3 or 4 days for routine prevention of angioedema attack. An IV infusion takes about 10 minutes to complete.

Complement C1 esterase inhibitor is a dry powder that must be mixed with a liquid (diluent) before using it. If you do not receive the diluent with your medication at the pharmacy, talk to your pharmacist.

If you are using the injections at home, be sure you understand how to properly mix and store the medication. Do not mix the medicine until you are ready to give the injection.

Complement C1 esterase inhibitor contains no preservative. Once you have pierced the rubber top of a vial with a needle, you must use that vial right away or throw it away.

Each single-use vial (bottle) of this medicine is for one use only. Throw away the vial after one use, even if there is still some medicine left in it after injecting your dose.

After mixing complement C1 esterase inhibitor with the diluent, use it right away or store the mixture at room temperature and use it within 3 hours. The mixed medicine should be clear or slightly blue in color. Do not use the mixed medication if it has changed colors, is cloudy, or has any particles in it.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Store the unmixed dry powder in a refrigerator or in a dark cool place. Keep the medicine protected from light and do not allow it to freeze. Throw away any unused vial after the expiration date on the label has passed.