Cipro I.V. (Ciprofloxacin IV) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Cipro IV

Swimmer's Ear »

Swimmer's ear facts

Swimmer's ear, or external otitis, is typically a bacterial infection of the outer ear canal skin and can occur in acute and chronic forms.
Excessive water exposure and frequent instrumentation (usually cotton swabs) of the ear canal are important causative factors.
Itchy ears, a feeling of fullness, swelling, drainage, and pain are early symptoms.
Antibiotic ear drops and avoidance of water are frequently necessary for treatment.
Proper ear care can avoid most infections.

What is "swimmer's ear" or acute external otitis?

External otitis or "swimmer's ear" is an infection of the skin covering the outer ear and ear canal. Acute external otitis is commonly a bacterial infection caused by streptococcus, staphylococcus, or pseudomonas types of bacteria. The swimmer's ear infection is usually caused by excessive water exposure from sw...

Read the Swimmer's Ear article »

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CIPRO® I.V.
(ciprofloxacin) For Intravenous Infusion

WARNING

Fluoroquinolones, including CIPRO® I.V. (ciprofloxacin iv) , are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants (See WARNINGS).

To reduce the development of drug-resistant bacteria and maintain the effectiveness of CIPRO I.V. (ciprofloxacin iv) and other antibacterial drugs, CIPRO I.V. (ciprofloxacin iv) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

CIPRO I.V. (ciprofloxacin) is a synthetic broad-spectrum antimicrobial agent for intravenous (I.V.) administration. Ciprofloxacin, a fluoroquinolone, is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid. Its empirical formula is C₁₇H₁₈FN₃O₃ and its chemical structure is:

CIPRO® I.V.
(ciprofloxacin) Structural Formula Illustration

Ciprofloxacin is a faint to light yellow crystalline powder with a molecular weight of 331.4. It is soluble in dilute (0.1N) hydrochloric acid and is practically insoluble in water and ethanol. CIPRO I.V. (ciprofloxacin iv) solutions are available as sterile 1% aqueous concentrates, which are intended for dilution prior to administration, and as 0.2% ready-for-use infusion solutions in 5% Dextrose Injection. All formulas contain lactic acid as a solubilizing agent and hydrochloric acid for pH adjustment. The pH range for the 1% aqueous concentrates in vials is 3.3 to 3.9. The pH range for the 0.2% ready-for-use infusion solutions is 3.5 to 4.6.

The plastic container is latex-free and is fabricated from a specially formulated polyvinyl chloride. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di(2-ethylhexyl) phthalate (DEHP), up to 5 parts per million. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

What are the precautions when taking ciprofloxacin iv (Cipro I.V.)?

Before using ciprofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., gatifloxacin, levofloxacin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizure disorder, conditions that increase your risk of seizures (e.g., brain/head injury, brain tumors), nervous system disorders (e.g., peripheral neuropathy), kidney disease, liver disease, myasthenia gravis, joint/tendon problems (e.g., tendonitis, bursitis), heart problems (e.g., slow/fast/irregular heartbeat, recent heart...

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Last reviewed on RxList: 12/30/2008
This monograph has been modified to include the generic and brand name in many instances.