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(ciprofloxacin) for Intravenous Infusion
TENDON EFFECTS and MYASTHENIA GRAVIS
Fluoroquinolones, including CIPRO IV®, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart, or lung transplants [see WARNINGS AND PRECAUTIONS].
Fluoroquinolones, including CIPRO IV, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid CIPRO IV in patients with known history of myasthenia gravis [see WARNINGS AND PRECAUTIONS].
CIPRO IV (ciprofloxacin) is a synthetic antimicrobial agent for intravenous (IV) administration. Ciprofloxacin, a fluoroquinolone, is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1piperazinyl)-3quinolinecarboxylic acid. Its empirical formula is C17H18FN3O3 and its chemical structure is:
Ciprofloxacin is a faint to light yellow crystalline powder with a molecular weight of 331.4. It is soluble in dilute (0.1N) hydrochloric acid and is practically insoluble in water and ethanol. CIPRO IV solutions are available as sterile 0.2% ready-for-use infusion solutions in 5% Dextrose Injection. CIPRO IV contains lactic acid as a solubilizing agent and hydrochloric acid for pH adjustment. The pH range for the 0.2% ready-for-use infusion solutions is 3.5 to 4.6.
The plastic container is not made with natural rubber latex.. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, for example, di(2-ethylhexyl) phthalate (DEHP), up to 5 parts per million. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.
The glucose content for the 200 mL flexible container is 10 g.
What are the precautions when taking ciprofloxacin iv (Cipro I.V.)?
Before using ciprofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (such as gatifloxacin, levofloxacin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, conditions that increase your risk of seizures (such as brain/head injury, brain tumors, cerebral atherosclerosis), nerve problems (such as peripheral neuropathy), kidney disease, liver disease, myasthenia gravis, joint/tendon problems (such as tendonitis, bursitis), heart problems (such as slow/fast/irregular heartbeat, recent heart...
Last reviewed on RxList: 4/13/2015
This monograph has been modified to include the generic and brand name in many instances.
Additional Cipro I.V. Information
Cipro I.V. - User Reviews
Cipro I.V. User Reviews
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