Inflammatory Bowel Disease (Intestinal Problems of IBD) »
Ulcerative colitis (UC) and Crohn's disease (CD) are known as the inflammatory bowel diseases (IBD). The precise cause of IBD remains unknown. These diseases are believed to be caused by a combination of genetic and non-genetic, or environmental factors (for example, infections) that interact with the body's immune (defense) system. When the intestinal immune system does not function properly, many white blood cells accumulate in the inner lining (mucosa) of the gut. The white cells then release chemicals that lead to tissue injury (inflammation). This inflammation of the mucosa can cause diarrhea, which is the most common symptom of ulcerative colitis and Crohn's disease, with or without the intestinal complications.
The intestinal complications of IBD occur when the intestinal inflammation is severe, extends beyond the inner lining (m...
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CIPRO® I.V.
(ciprofloxacin) For Intravenous Infusion
WARNING
Fluoroquinolones, including CIPRO® I.V. (ciprofloxacin iv) , are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants (See WARNINGS).
To reduce the development of drug-resistant bacteria and maintain the effectiveness of CIPRO I.V. (ciprofloxacin iv) and other antibacterial drugs, CIPRO I.V. (ciprofloxacin iv) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
CIPRO I.V. (ciprofloxacin) is a synthetic broad-spectrum antimicrobial agent for intravenous (I.V.) administration. Ciprofloxacin, a fluoroquinolone, is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid. Its empirical formula is C17H18FN3O3 and its chemical structure is:
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Ciprofloxacin is a faint to light yellow crystalline powder with a molecular weight of 331.4. It is soluble in dilute (0.1N) hydrochloric acid and is practically insoluble in water and ethanol. CIPRO I.V. (ciprofloxacin iv) solutions are available as sterile 1% aqueous concentrates, which are intended for dilution prior to administration, and as 0.2% ready-for-use infusion solutions in 5% Dextrose Injection. All formulas contain lactic acid as a solubilizing agent and hydrochloric acid for pH adjustment. The pH range for the 1% aqueous concentrates in vials is 3.3 to 3.9. The pH range for the 0.2% ready-for-use infusion solutions is 3.5 to 4.6.
The plastic container is latex-free and is fabricated from a specially formulated polyvinyl chloride. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di(2-ethylhexyl) phthalate (DEHP), up to 5 parts per million. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.
Before using ciprofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., gatifloxacin, levofloxacin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizure disorder, conditions that increase your risk of seizures (e.g., brain/head injury, brain tumors), nervous system disorders (e.g., peripheral neuropathy), kidney disease, liver disease, myasthenia gravis, joint/tendon problems (e.g., tendonitis, bursitis), heart problems (e.g., slow/fast/irregular heartbeat, recent heart...
Last reviewed on RxList: 12/30/2008
This monograph has been modified to include the generic and brand name in many instances.
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