Ciprodex (Ciprofloxacin and Dexamethasone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Ciprodex

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CIPRODEX®
(ciprofloxacin 0.3% and dexamethasone 0.1%)
Sterile Otic Suspension

DRUG DESCRIPTION

CIPRODEX® (ciprofloxacin 0.3% and dexamethasone 0.1%) Sterile Otic Suspension contains the synthetic broad-spectrum antibacterial agent, ciprofloxacin hydrochloride, combined with the anti-inflammatory corticosteroid, dexamethasone, in a sterile, preserved suspension for otic use. Each mL of CIPRODEX® (ciprofloxacin and dexamethasone ) Otic contains ciprofloxacin hydrochloride (equivalent to 3 mg ciprofloxacin base), 1 mg dexamethasone, and 0.1 mg benzalkonium chloride as a preservative. The inactive ingredients are boric acid, sodium chloride, hydroxyethyl cellulose, tyloxapol, acetic acid, sodium acetate, edetate disodium, and purified water. Sodium hydroxide or hydrochloric acid may be added for adjustment of pH.

Ciprofloxacin, a fluoroquinolone is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. The empirical formula is C₁₇H₁₈FN₃O₃•HCl•H₂O and the structural formula is:

CIPRODEX® (ciprofloxacin 0.3% and dexamethasone 0.1%) Structural Formula Illustration

Dexamethasone, 9-fluoro-11(beta),17,21-trihydroxy-16(alpha)-methylpregna-1,4-diene-3,20-dione, is an anti-inflammatory corticosteroid. The empirical formula is C₂₂H₂₉FO₅ and the structural formula is:

What are the possible side effects of ciprofloxacin and dexamethasone otic (Ciprodex)?

Stop using ciprofloxacin and dexamethasone otic and seek emergency medical attention or notify your doctor if you experience:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
skin rash; or
ear drainage, discharge, or worsening pain.

Other less serious side effects may also occur such as ear discomfort or itching or an unusual taste in the mouth. Continue to use the medication and talk to your doctor if...

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What are the precautions when taking ciprofloxacin and dexamethasone (Ciprodex)?

Before using this medication, tell your doctor or pharmacist if you are allergic to quinolone antibiotics (e.g., ciprofloxacin, levofloxacin), or to corticosteroids (e.g., dexamethasone, prednisone); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an ear infection caused by a virus (e.g., herpes simplex).

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly...

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Last reviewed on RxList: 8/17/2007
This monograph has been modified to include the generic and brand name in many instances.