"Researchers have spotted the first known instance of bacteria impervious to the last-resort antibiotic colistin in the United States, exacerbating fears of superbugs that can turn an ordinary infection deadly.
The case involves a 49-y"...
(ciprofloxacin and dexamethasone), Sterile Otic Suspension
CIPRODEX (ciprofloxacin 0.3% and dexamethasone 0.1%) Sterile Otic Suspension contains the quinolone antimicrobial, ciprofloxacin hydrochloride, combined with the corticosteroid, dexamethasone, in a sterile, preserved suspension for otic use. Each mL of CIPRODEX contains ciprofloxacin hydrochloride (equivalent to 3 mg ciprofloxacin base), 1 mg dexamethasone, and 0.1 mg benzalkonium chloride as a preservative. The inactive ingredients are boric acid, sodium chloride, hydroxyethyl cellulose, tyloxapol, acetic acid, sodium acetate, edetate disodium, and purified water. Sodium hydroxide or hydrochloric acid may be added for adjustment of pH.
Ciprofloxacin, a quinolone antimicrobial is available as the monohydrochloride monohydrate salt of 1- cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid. The empirical formula is C17H18FN3O3•HCl•H2O. The molecular weight is 385.82 and the structural formula is:
Figure 1: Structure of Ciprofloxacin
Dexamethasone, 9-fluoro-11(beta),17,21-trihydroxy-16(alpha)-methylpregna-1,4-diene-3,20-dione, is a corticosteroid. The empirical formula is C22H29FO5. The molecular weight is 392.46 and the structural formula is:
Figure 2: Structure of Deamethasone
What are the possible side effects of ciprofloxacin and dexamethasone otic (Ciprodex)?
Stop using ciprofloxacin and dexamethasone otic and seek emergency medical attention or notify your doctor if you experience:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- skin rash; or
- ear drainage, discharge, or worsening pain.
Other less serious side effects may also occur such as ear discomfort or itching or an unusual taste in the mouth. Continue to use the medication and talk to your doctor if these side effects seem excessive or unusual.
What are the precautions when taking ciprofloxacin and dexamethasone (Ciprodex)?
Before using this medication, tell your doctor or pharmacist if you are allergic to quinolone antibiotics (e.g., ciprofloxacin, levofloxacin), or to corticosteroids (e.g., dexamethasone, prednisone); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an ear infection caused by a virus (e.g., herpes simplex).
Before using this medication, tell your doctor or pharmacist your medical history.
This medication should be used only when clearly...
Last reviewed on RxList: 9/21/2016
This monograph has been modified to include the generic and brand name in many instances.
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