Cisplatin (Cisplatin Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Cisplatin

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Cancer is the uncontrolled growth of abnormal cells anywhere in a body. The abnormal cells are termed cancer cells, malignant cells, or tumor cells. Many cancers and the abnormal cells that compose the cancer tissue are further identified by the name of the tissue that the abnormal cells originated from (for example, breast cancer, lung cancer, colon cancer). Cancer is not confined to humans; animals and other living organisms can get cancer. Below is a schematic that shows normal cell division and how when a cell is damaged or altered without repair to its system, the cell usually dies. Also shown is what can occur when such damaged or unrepaired cells do not die and become cancer cells and proliferate with uncontrolled growth; a mass of cancer cells develop. Frequently, cancer cells can break away from this original mass of cells, travel through the blood and lymph systems, and lodge in other organs where they can again repeat the ...

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Cisplatin User Reviews >>

Cisplatin

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Cisplatin Injection
(generic)

WARNINGS

Cisplatin injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available.

Cumulative renal toxicity associated with cisplatin (cisplatin injection) is severe. Other major dose-related toxicities are myelo-suppression, nausea, and vomiting.

Ototoxicity, which may be more pronounced in children, and is manifested by tinnitus, and/or loss of high frequency hearing and occasionally deafness, is significant.

Anaphylactic-like reactions to cisplatin (cisplatin injection) have been reported. Facial edema, bronchoconstriction, tachycardia, and hypotension may occur within minutes of cisplatin (cisplatin injection) administration. Epinephrine, corticosteriods, and antihistamines have been effectively employed to alleviate symptoms (see WARNINGS and ADVERSE REACTIONS sections).

Exercise caution to prevent inadvertent cisplatin (cisplatin injection) overdose. Doses greater than 100 mg/m²/cycle once every 3 to 4 weeks are rarely used. Care must be taken to avoid inadvertent cisplatin (cisplatin injection) overdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle.

DRUG DESCRIPTION

Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose vials, each mL containing 1 mg of cisplatin (cisplatin injection) and 9 mg sodium chloride in water for injection. HCI and/or sodium hydroxide added to adjust pH to 3.5 to 4.5.

Cisplatin (cisplatin injection) (cis-diamminedichloroplatinum) is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. It is a white powder with the molecular formula PtCl₂H₆N₂, and a molecular weight of 300.05. It is soluble in water or saline at 1 mg/mL and in dimethylformamide at 24 mg/mL. It has a melting point of 207°C.

CISPLATIN Structural Formula Illustration

What are the precautions when taking cisplatin injection (Cisplatin)?

Before using cisplatin, tell your doctor or pharmacist if you are allergic to it; or to carboplatin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney disease, decreased bone marrow function/blood cell disorders (e.g., anemia, leukopenia, thrombocytopenia), hearing problems.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: mineral imbalance (low blood levels of sodium, potassium, magnesium, calcium, phosphate), numbness/tingling of the...

Read All Potential Precautions of Cisplatin »

Last reviewed on RxList: 6/13/2008
This monograph has been modified to include the generic and brand name in many instances.