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Cisplatin injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available.
Cumulative renal toxicity associated with cisplatin (cisplatin injection) is severe. Other major dose-related toxicities are myelo-suppression, nausea, and vomiting.
Ototoxicity, which may be more pronounced in children, and is manifested by tinnitus, and/or loss of high frequency hearing and occasionally deafness, is significant.
Anaphylactic-like reactions to cisplatin (cisplatin injection) have been reported. Facial edema, bronchoconstriction, tachycardia, and hypotension may occur within minutes of cisplatin (cisplatin injection) administration. Epinephrine, corticosteriods, and antihistamines have been effectively employed to alleviate symptoms (see WARNINGS and ADVERSE REACTIONS sections).
Exercise caution to prevent inadvertent cisplatin (cisplatin injection) overdose. Doses greater than 100 mg/m2/cycle once every 3 to 4 weeks are rarely used. Care must be taken to avoid inadvertent cisplatin (cisplatin injection) overdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle.
Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose vials, each mL containing 1 mg of cisplatin (cisplatin injection) and 9 mg sodium chloride in water for injection. HCI and/or sodium hydroxide added to adjust pH to 3.5 to 4.5.
Cisplatin (cisplatin injection) (cis-diamminedichloroplatinum) is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. It is a white powder with the molecular formula PtCl2H6N2, and a molecular weight of 300.05. It is soluble in water or saline at 1 mg/mL and in dimethylformamide at 24 mg/mL. It has a melting point of 207°C.
Last reviewed on RxList: 6/13/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Cisplatin Information
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