Cisplatin (Cisplatin Injection) Drug Information: Overdosage and Contraindications

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May 26, 2012

Cisplatin

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OVERDOSE

Caution should be exercised to prevent inadvertent overdosage with cisplatin (cisplatin injection) . Acute overdosage with this drug may result in kidney failure, liver failure, deafness, ocular toxicity (including detachment of the retina), significant myelosuppression, intractable nausea and vomiting and/or neuritis. In addition, death can occur following overdosage.

No proven antidotes have been established for cisplatin (cisplatin injection) overdosage. Hemodialysis, even when initiated four hours after the overdosage, appears to have little effect on removing platinum from the body because of cisplatin (cisplatin injection) 's rapid and high degree of protein binding. Management of overdosage should include general supportive measures to sustain the patient through any period of toxicity that may occur.

CONTRAINDICATIONS

Cisplatin (cisplatin injection) is contraindicated in patients with preexisting renal impairment. Cisplatin (cisplatin injection) should not be employed in myelosuppressed patients, or patients with hearing impairment.

Cisplatin (cisplatin injection) is contraindicated in patients with a history of allergic reactions to cisplatin (cisplatin injection) or other platinum-containing compounds.

Last reviewed on RxList: 6/13/2008
This monograph has been modified to include the generic and brand name in many instances.