July 28, 2016
Recommended Topic Related To:

Claforan

"Hand, foot, and mouth disease is a contagious viral illness. It commonly affects infants and young children. There is no vaccine to prevent the disease. However, you can take simple steps to reduce your risk.

Hand, foot, and mouth disease"...

A A A

Claforan




Overdosage
Contraindications

OVERDOSE

The acute toxicity of CLAFORAN was evaluated in neonatal and adult mice and rats. Significant mortality was seen at parenteral doses in excess of 6000 mg/kg/day in all groups. Common toxic signs in animals that died were a decrease in spontaneous activity, tonic and clonic convulsions, dyspnea, hypothermia, and cyanosis. Cefotaxime sodium overdosage has occurred in patients. Most cases have shown no overt toxicity. The most frequent reactions were elevations of BUN and creatinine. There is a risk of reversible encephalopathy in cases of administration of high doses of beta-lactam antibiotics including cefotaxime. No specific antidote exists. Patients who receive an acute overdosage should be carefully observed and given supportive treatment.

CONTRAINDICATIONS

CLAFORAN is contraindicated in patients who have shown hypersensitivity to cefotaxime sodium, or the cephalosporin group of antibiotics.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 3/10/2014

Overdosage
Contraindications

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.