Clarinex-D 12hr (Desloratadine and Pseudoephedrine Sulfate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Clarinex-D 12hr

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The arsenal of allergy drugs includes dozens of medications that relieve allergy symptoms when confronted with a trigger known as an allergen. That trigger could be something from a plant, such as pollen, or something from an animal (pet dander, dust mites, cockroaches). Other allergy triggers include certain fragrances or chemical substances.

What causes a person's allergic reaction is highly individual. But the reactions are often universal: swelling and inflammation, especially around the eyes, nose, and throat, usually accompanied by itching.

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Clarinex-D 12hr

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CLARINEX-D® 12 HOUR
(desloratadine 2.5 mg and pseudoephedrine sulfate, USP 120 mg) Extended Release Tablets

DRUG DESCRIPTION

CLARINEX-D®12 HOUR Extended Release Tablets are oval shaped blue and white bilayer tablets containing 2.5 mg desloratadine in the blue immediate-release layer and 120 mg of pseudoephedrine sulfate, USP in the white extended-release layer which is released slowly, allowing for twice-daily administration.

The inactive ingredients contained in CLARINEX-D®12 HOUR Extended Release Tablets are hypromellose USP, microcrystalline cellulose NF, povidone USP, silicon dioxide NF, magnesium stearate NF, corn starch NF, edetate disodium USP, citric acid anhydrous USP, stearic acid NF and FD&C Blue No. 2 aluminum lake dye.

Desloratadine, one of the two active ingredients of CLARINEX-D®12 HOUR Extended Release Tablets, is a white to off-white powder that is slightly soluble in water, but very soluble in ethanol and propylene glycol. It has an empirical formula: C₁₉H₁₉ClN₂ and molecular weight of 310.8. The chemical name is 8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5H-benzo[5,6] cyclohepta [1,2-b]pyridine and has the following structure:

Desloratadine Structural Formula Illustration

Pseudoephedrine sulfate, the other active ingredient of CLARINEX-D®12 HOUR Extended Release Tablets, is the synthetic salt of one of the naturally occurring dextrorotatory diastereomer of ephedrine and is classified as an indirect sympathomimetic amine. Pseudoephedrine sulfate is a colorless hygroscopic crystal or white, hygroscopic crystalline powder, practically odorless, with a bitter taste. It is very soluble in water, freely soluble in alcohol, and sparingly soluble in ether. The empirical formula for pseudoephedrine sulfate is (C₁₀H₁₅NO)₂ •H₂SO₄; the chemical name is benzenemethanol, α-[1-(methylamino) ethyl]-,[S-(R*,R*)]-, sulfate (2:1)(salt); and the chemical structure is:

Pseudoephedrine sulfate Structural Formula Illustration

What are the possible side effects of desloratadine and pseudoephedrine (Clarinex-D 12 Hour, Clarinex-D 24 Hour)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

fast, pounding, or uneven heartbeat;
confusion, hallucinations, unusual thoughts or behavior;
severe dizziness, anxiety, restless feeling, or nervousness;
increased blood pressure...

Read All Potential Side Effects and See Pictures of Clarinex-D 12hr »

What are the precautions when taking desloratadine and pseudoephedrine sulfate (Clarinex-D 12hr)?

Before taking desloratadine with pseudoephedrine, tell your doctor or pharmacist if you are allergic to it; or to loratadine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: glaucoma (narrow-angle type), severe difficulty urinating (urinary retention), severe high blood pressure, severe heart/blood vessel disease (e.g., coronary artery disease), history of a certain serious side effect with decongestants (irregular heart rhythm).

Before using this medication, tell your doctor or pharmacist your...

Read All Potential Precautions of Clarinex-D 12hr »

Last reviewed on RxList: 2/4/2009
This monograph has been modified to include the generic and brand name in many instances.