Clarinex-D 24hr (Desloratadine and Pseudoephedrine Sulfate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Clarinex-D 24hr

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What are hives (urticaria) and angioedema?

Hives (medically known as urticaria) appear on the skin as wheals which are red, very itchy, smoothly elevated areas of skin often with a blanched center. They appear in varying shapes and sizes, from a few millimeters to several inches in diameter anywhere on the body.

It is estimated that 20% of all people will develop urticaria at some point in their lives. Hives are more common in women than in men. One hallmark of hives is their tendency to change size rapidly and to move around, disappearing in one place and reappearing in other places, often in a matter of hours. Individual hives usually last no longer than 24 hours. An outbreak that looks impressive, even alarming, first thing in the morning can be completely gone by noon, only to be back in full force later in the day. Very few, if any other skin diseases occur and then resolve so rapidly. Therefore, even if you have no evidence of hives to show the doctor ...

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Clarinex-D 24hr User Reviews >>

Clarinex-D 24hr

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CLARINEX-D 24 HOUR Extended Release
(desloratadine/pseudoephedrine sulfate)

DRUG DESCRIPTION

CLARINEX-D 24 HOUR Extended Release Tablets are light blue oval-shaped tablets containing 5 mg desloratadine in the tablet coating for immediate release and 240 mg pseudoephedrine sulfate USP in the tablet core for extended release.

The inactive ingredients contained in CLARINEX-D 24 HOUR Extended Release Tablets are hypromellose USP, ethylcellulose NF, dibasic calcium phosphate dihydrate USP, magnesium stearate NF, povidone USP, silicone dioxide NF, talc USP, polyacrylate dispersion, polyethylene glycol NF, simethicone USP, Blue Lake Blend 50726 (FD&C Blue No. 2 Lake, titanium dioxide USP and edetate disodium USP), and ink (Opacode® S-1-17746 or Opacode® S-1-4159).

Desloratadine, 1 of the 2 active ingredients of CLARINEX-D 24 HOUR Extended Release Tablets, is a white to off-white powder that is slightly soluble in water, but very soluble in ethanol and propylene glycol. It has an empirical formula: C₁₉H₁₉ClN₂ and a molecular weight of 310.8. The chemical name is 8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine and has the following structure:

Desloratadine Structural Formula Illustration

Pseudoephedrine sulfate, the other active ingredient of CLARINEX-D 24 HOUR Extended Release Tablets, is the synthetic salt of one of the naturally occurring dextrorotatory diastereomers of ephedrine and is classified as an indirect sympathomimetic amine. Pseudoephedrine sulfate is a colorless hygroscopic crystal or white, hygroscopic crystalline powder, practically odorless, with a bitter taste. It is very soluble in water, freely soluble in alcohol, and sparingly soluble in ether. The empirical formula for pseudoephedrine sulfate is (C₁₀H₁₅NO)₂• H₂SO₄; the chemical name is benzenemethanol, α-[1-(methylamino) ethyl]-,[S-(R*,R*)]-, sulfate (2:1)(salt); and the chemical structure is:

Pseudoephedrine sulfate Structural Formula Illustration

What are the possible side effects of desloratadine and pseudoephedrine (Clarinex-D 12 Hour, Clarinex-D 24 Hour)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

fast, pounding, or uneven heartbeat;
confusion, hallucinations, unusual thoughts or behavior;
severe dizziness, anxiety, restless feeling, or nervousness;
increased blood pressure...

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What are the precautions when taking desloratadine and pseudoephedrine sulfate (Clarinex-D 24hr)?

Before taking desloratadine with pseudoephedrine, tell your doctor or pharmacist if you are allergic to it; or to loratadine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: glaucoma (narrow-angle type), severe difficulty urinating (urinary retention), severe high blood pressure, severe heart/blood vessel disease (e.g., coronary artery disease), history of a certain serious side effect with decongestants (irregular heart rhythm).

Before using this medication, tell your doctor or pharmacist your...

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Last reviewed on RxList: 8/26/2011
This monograph has been modified to include the generic and brand name in many instances.