Clarinex (Desloratadine) Drug Information: Overdosage and Contraindications

Pill Identifier Search

May 26, 2012

Clarinex

Eye Allergy »

Eye allergy facts

Most allergic eye conditions are more irritating than dangerous.
Allergic or vernal keratoconjunctivitis may result in scarring of the cornea and visual problems.
Itchy eyes are probably allergic eyes.
Topical antihistamine/decongestant preparations are effective and safe for mildly itchy, red eyes.
Patanol, a topical mast-cell stabilizer, is a safe, highly effective, long-acting treatment.
Topical steroids should be used with caution and under the supervision of an ophthalmologist.
If in doubt, seek medical advice sooner rather than later.

Eye allergy introduction

The eyes are the windows to the soul because they reflect our state of mind. This certainly can't be true if our eyes are red, swollen, watery, and itchy from an allergic reaction. Severe allergic eye symptoms can be very distressing and are a common reason fo...

Read the Eye Allergy article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
Next »

Clarinex User Reviews >>

Clarinex

10 Common Allergy Triggers Slideshow Pictures

Take the Quiz on Allergies

Nasal Allergy Relief Slideshow Pictures

font size

OVERDOSE

Information regarding acute overdosage is limited to experience from clinical trials conducted during the development of the CLARINEX (desloratadine) product. In a dose ranging trial, at doses of 10 mg and 20 mg/day somnolence was reported.

Single daily doses of 45 mg were given to normal male and female volunteers for 10 days. All ECGs obtained in this study were manually read in a blinded fashion by a cardiologist. In CLARINEX (desloratadine) -treated subjects, there was an increase in mean heart rate of 9.2 bpm relative to placebo. The QT interval was corrected for heart rate (QTc) by both the Bazett and Fridericia methods. Using the QTc (Bazett) there was a mean increase of 8.1 msec in CLARINEX (desloratadine) -treated subjects relative to placebo. Using QTc (Fridericia) there was a mean increase of 0.4 msec in CLARINEX (desloratadine) -treated subjects relative to placebo. No clinically relevant adverse events were reported.

In the event of overdose, consider standard measures to remove any unabsorbed drug. Symptomatic and supportive treatment is recommended. Desloratadine and 3-hydroxydesloratadine are not eliminated by hemodialysis.

Lethality occurred in rats at oral doses of 250 mg/kg or greater (estimated desloratadine and desloratadine metabolite exposures were approximately 120 times the AUC in humans at the recommended daily oral dose). The oral median lethal dose in mice was 353 mg/kg (estimated desloratadine exposures were approximately 290 times the human daily oral dose on a mg/m² basis). No deaths occurred at oral doses up to 250 mg/kg in monkeys (estimated desloratadine exposures were approximately 810 times the human daily oral dose on a mg/m² basis).

CONTRAINDICATIONS

CLARINEX (desloratadine) Tablets 5 mg are contraindicated in patients who are hypersensitive to this medication or to any of its ingredients, or to loratadine.

Last reviewed on RxList: 7/10/2009
This monograph has been modified to include the generic and brand name in many instances.