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Loratadine; pseudoephedrine sulfate extended release tablets are indicated for the relief of symptoms of seasonal allergic rhinitis. Loratadine; pseudoephedrine sulfate extended release tablets should be administered when both the antihistaminic properties of loratadine and the nasal decongestant activity of pseudoephedrine are desired (see CLINICAL PHARMACOLOGY).
DOSAGE AND ADMINISTRATION
Adults and Children 12 Years of Age and Over: 12 Hour Tablet: One tablet twice a day (every 12 hours); 24 Hour Tablet: One tablet daily taken with a full glass of water (see PRECAUTIONS and ADVERSE REACTIONS). Because the doses of this fixed combination product cannot be individually titrated and hepatic insufficiency results in a reduced clearance of loratadine to a much greater extent than pseudoephedrine, loratadine; pseudoephedrine sulfate extended release tablets should generally be avoided in patients with hepatic insufficiency. Patients with renal insufficiency (GFR <30 ml/min) should be given a lower initial dose (one 12 hour tablet per day, or one 24 hour tablet every other day) because they have reduced clearance of loratadine and pseudoephedrine. Patients who have a history of difficulty in swallowing tablets or who have known upper gastrointestinal narrowing or abnormal esophageal peristalsis should not use the 24 hour tablet (see PRECAUTIONS, Information for the Patient; and ADVERSE REACTIONS).
Claritin-D 12 Hour Extended Release Tablets
Claritin-D 12 hour extended release tablets contain 5 mg loratadine and 120 mg pseudoephedrine sulfate. Claritin-D 12 hour extended release tablets are white tablets branded in green with "CLARITIN-D".
Storage: Keep Unit-of-Use packaging and Unit Dose-Hospital Pack in a dry place. Store between 2-25°C (36-77°F).
Claritin-D 24 Hour Extended Release Tablets
Claritin-D 24 hour extended release tablets contain 10 mg loratadine in the tablet coating for immediate release and 240 mg pseudoephedrine sulfate in an extended-release core. Claritin-D 24 hour extended release tablets are white to off-white oval, biconvex, coated tablets branded in black with "CLARITIN-D 24 HOUR".
Storage: Protect Unit Dose-Hospital Pack from light and store in a dry place. Store between 15-25°C (59-77°F).
This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
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