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Cleocin IV Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Cleocin (clindamycin) is an antibiotic used for the treatment of serious infections caused by susceptible anaerobic bacteria. A generic formulation of Cleocin is available. Side effects of Cleocin include abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting, diarrhea, unpleasant or metallic taste in mouth (if Cleocin is injected into a vein), or pain at the injection site (if Cleocin is injected into a muscle).
The recommended dose of Cleocin for adults is 150-450 mg orally every 6 hours or intravenous doses of 600-2700 mg daily in 2-4 divided doses. Cleocin may interact with other neuromuscular blocking agents, erythromycin, and hormonal birth control. Tell your doctor all medications and supplements you use. Cleocin has not been adequately evaluated in pregnant women. Cleocin should be used during pregnancy only if it is clearly needed. Cleocin is excreted in breast milk and may cause adverse effects in the infant.
Our Cleocin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Cleocin IV Overview - Patient Information: Side Effects
Nausea, vomiting, an unpleasant/metallic taste in mouth (if this drug is injected into a vein), or pain at the injection site (if this drug is injected into a muscle) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: pain/swelling at injection site (if this drug is injected into a vein), dark urine, yellowing eyes/skin, persistent nausea/vomiting, change in the amount of urine, easy bruising/bleeding, pain in several joints, new signs of infection (e.g., fever, persistent sore throat), fast/slow/irregular heartbeat, fainting.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Cleocin IV (Clindamycin)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Cleocin IV FDA Prescribing Information: Side Effects
The following reactions have been reported with the use of clindamycin.
Gastrointestinal: Antibiotic-associated colitis (see WARNINGS), pseudomembranous colitis, abdominal pain, nausea, and vomiting. The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS). An unpleasant or metallic taste occasionally has been reported after intravenous administration of the higher doses of clindamycin phosphate.
Hypersensitivity Reactions: Maculopapular rash and urticaria have been observed during drug therapy. Generalized mild to moderate morbilliform-like skin rashes are the most frequently reported of all adverse reactions. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with clindamycin. A few cases of anaphylactoid reactions have been reported. If a hypersensitivity reaction occurs, the drug should be discontinued. The usual agents (epinephrine, corticosteroids, antihistamines) should be available for emergency treatment of serious reactions.
Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.
Renal: Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.
Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.
Local Reactions: Pain, induration and sterile abscess have been reported after intramuscular injection and thrombophlebitis after intravenous infusion. Reactions can be minimized or avoided by giving deep intramuscular injections and avoiding prolonged use of indwelling intravenous catheters.
Musculoskeletal: Rare instances of polyarthritis have been reported.
Read the entire FDA prescribing information for Cleocin IV (Clindamycin)
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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