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home > drugs a-z list > cleocin t (clindamycin topical) drug center > cleocin t (clindamycin topical) drug - side effects and drug interactions
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Cleocin T
What is acne?
Acne (acne vulgaris, common acne) is a disease of the hair follicles of the face, chest, and back that affects almost all males and females during puberty; the only exception being teenage members of a few primitive isolated tribes living in Neolithic societies. It is not caused by bacteria, although bacteria play a role in its development. It is not unusual for some women to develop acne in their mid- to late-20s.
Acne appears on the skin as...
- congested pores ("comedones"), also known as blackheads or whiteheads,
- tender red bumps also known as pimples or zits,
- pustules, and occasionally as
- cysts (deep pimples, boils).
You can do a lot to treat your acne using products available at a drugstore or cosmetic counter that do not require a prescription. However, for tougher cases of acne, you should consult a physician for treatment options.
What...
Cleocin T
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SIDE EFFECTS
In 18 clinical studies of various formulations of CLEOCIN T (clindamycin topical) using placebo vehicle and/or active comparator drugs as controls, patients experienced a number of treatment emergent adverse dermatologic events [see table below].
Number of Patients Reporting Events
| Treatment Emergent Adverse Event | Solution n=553 (%) |
Gel n=148 (%) |
Lotion n=160 (%) |
| Burning | 62 (11) | 15 (10) | 17 (11) |
| Itching | 36 ( 7) | 15 (10) | 17 (11) |
| Burning/Itching | 60 (11) | # ( - ) | # ( - ) |
| Dryness | 105 (19) | 34 (23) | 29 (18) |
| Erythema | 86 (16) | 10 ( 7) | 22 (14) |
| Oiliness/Oily Skin | 8 ( 1) | 26 (18) | 12* (10) |
| Peeling | 61 (11) | # ( - ) | 11 ( 7) |
| # not recorded * of 126 subjects |
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Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally.
Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see WARNINGS).
Abdominal pain and gastrointestinal disturbances as well as gram-negative folliculitis have also been reported in association with the use of topical formulations of clindamycin.
DRUG INTERACTIONS
Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore it should be used with caution in patients receiving such agents.
Last reviewed on RxList: 4/18/2008
This monograph has been modified to include the generic and brand name in many instances.
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