August 31, 2015
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Cleviprex

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Cleviprex

Cleviprex
(clevidipine) Injectable Emulsion, for Intravenous Use




DRUG DESCRIPTION

Cleviprex is a sterile, milky-white emulsion containing 0.5 mg/mL of clevidipine suitable for intravenous administration. Clevidipine is a dihydropyridine calcium channel blocker. Chemically, the active substance,clevidipine,is butyroxymethyl methyl 4-(2',3'-dichlorophenyl)-l,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate. It is a racemic mixture with a molecular weight of 456.3 g/mol. Each enantiomer has equipotent antihypertensive activity. The structure and formula are:

Cleviprex
  (clevidipine)Structural Formula Illustration

Clevidipineis practically insoluble in water and is formulated in an oil-in-water emulsion. In addition to the active ingredient, clevidipine, Cleviprex contains soybean oil(200 mg/mL), glycerin (22.5 mg/mL), purified egg yolk phospholipids (12 mg/mL),oleic acid (0.3 mg/mL), disodium edetate (0.05 mg/mL), and sodium hydroxide to adjust pH. Cleviprex has a pH of 6.0 - 8.0 and is a ready-to-use emulsion.

What are the possible side effects of clevidipine (Cleviprex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • rapid heart rate;
  • urinating less than usual or not at all;
  • weakness, confusion, increased thirst, loss of appetite, vomiting, pounding heartbeats or fluttering in your chest;
  • swelling, weight gain, feeling short of breath;
  • vomiting, diarrhea, stomach cramps, bloating,...

Read All Potential Side Effects and See Pictures of Cleviprex »

Last reviewed on RxList: 1/4/2012
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Hypertension

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