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home > drugs a-z list > cleviprex (clevidipine butyrate) drug center > cleviprex (clevidipine butyrate) drug - overdosage and contraindications
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Cleviprex
High Blood Pressure Treatment »
What is high blood pressure?
High blood pressure or hypertension means high pressure (tension) in the arteries. Arteries are vessels that carry blood from the pumping heart to all the tissues and organs of the body. High blood pressure does not mean excessive emotional tension, although emotional tension and stress can temporarily increase blood pressure. Normal blood pressure is below 120/80; blood pressure between 120/80 and 139/89 is called "pre-hypertension", and a blood pressure of 140/90 or above is considered high.
The top number, which is the systolic blood pressure, corresponds to the pressure in the arteries as the heart contracts and pumps blood into the arteries. The bottom number, the diastolic pressure, represents the pressure in the arteries as the heart relaxes after the contraction. The diastolic pressure reflects the lowest pressure to which the arteries are exposed.
An elevation of the systolic and/or diastolic blood pressure incre...
Cleviprex
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OVERDOSE
There has been no experience of overdosage in human clinical trials. In clinical trials, doses of Cleviprex up to 106 mg/hour or 1153 mg maximum total dose were administered. The expected major effects of overdose would be hypotension and reflex tachycardia.
Discontinuation of Cleviprex leads to a reduction in antihypertensive effects within 5 to 15 minutes [see CLINICAL PHARMACOLOGY]. In case of suspected overdosage, Cleviprex should be discontinued immediately and the patient's blood pressure should be supported.
CONTRAINDICATIONS
Known Allergy
Cleviprex is contraindicated in patients with allergies to soybeans, soy products, eggs, or egg products.
Defective Lipid Metabolism
Cleviprex is contraindicated in patients with defective lipid metabolism such as pathologic hyperlipemia, lipoid nephrosis, or acute pancreatitis if it is accompanied by hyperlipidemia.
Severe Aortic Stenosis
Cleviprex is contraindicated in patients with severeaortic stenosis because afterload reduction can be expected to reduce myocardial oxygen delivery.
Last reviewed on RxList: 1/4/2012
This monograph has been modified to include the generic and brand name in many instances.
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Additional Cleviprex Information
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Hypertension
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