May 26, 2017
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"SYDNEY, AUSTRALIA ” A small randomized trial reports sharp blood-pressure reductions in untreated hypertensives using a single pill combining four BP-lowering drugs at one-quarter the usual dose.

Among 18 patients, mean 24-hour systol"...



Cleviprex Patient Information including How Should I Take

What should I discuss with my healthcare provider before I receive clevidipine (Cleviprex)?

You should not receive this medication if you are allergic to clevidipine, eggs, or soy products. You also should not receive clevidipine if you have:

  • high cholesterol or triglyceride levels in your blood;
  • pancreatitis with high cholesterol or triglycerides;
  • a kidney disorder called lipoid nephrosis; or
  • severe narrowing of the aortic valve in your heart (aortic stenosis).

If possible before you receive clevidipine, tell your doctor if you have:

  • food allergies;
  • pancreatitis;
  • pheochromocytoma (an adrenal gland tumor);
  • heart disease; or
  • a history of high cholesterol.

FDA pregnancy category C. It is not known whether clevidipine is harmful to an unborn baby. Before you receive this medication, tell your doctor if you are pregnant.

It is not known whether clevidipine passes into breast milk or if it could harm a nursing baby. Before you receive this medication, tell your doctor if you are breast-feeding a baby.

In an emergency situation it may not be possible before you are treated with clevidipine to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How is clevidipine given (Cleviprex)?

Clevidipine is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. You will continue to receive clevidipine until you are able to take blood pressure medication orally (by mouth).

Your blood pressure and heart rate will be watched closely while you are receiving clevidipine. Your blood pressure may also need to be checked often for several hours after you stop receiving this medication.

While you are being treated with clevidipine, keep using your prescribed blood pressure medications even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

If you are also taking a beta-blocker (such as Betapace, Coreg, Corgard, Dutoprol, Inderal, InnoPran, Lopressor, Normodyne, Tenormin, Tenoretic, Toprol, Trandate, and others), do not suddenly stop using the beta blocker without first talking to your doctor. You may need to use less and less before you stop the medication completely. Stopping a beta blocker too quickly can cause serious heart problems that will not be prevented by clevidipine.

Clevidipine may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.

Side Effects Centers

Additional Cleviprex Information

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Get tips on handling your hypertension.