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(clindamycin phosphate) Vaginal Cream, 2%

For vaginal use only.

Do not put Clindesse (clindamycin phosphate) in your eyes, mouth, or on your skin.

Read this patient information before you start using Clindesse (clindamycin phosphate) . There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.

What is Clindesse (clindamycin phosphate) ?

Clindesse (clindamycin phosphate) is a vaginal cream medicine used to treat bacterial vaginal infections in women who are not pregnant.

It is not known if Clindesse (clindamycin phosphate) is safe and effective in pregnant women.

It is not known if Clindesse (clindamycin phosphate) is safe and effective in females who have not yet reached puberty.

Who should not use Clindesse (clindamycin phosphate) ?

Do not use Clindesse (clindamycin phosphate) if you:

  • have had an allergic reaction to clindamycin or other lincosamide antibiotic medicines or are allergic to any of the ingredients in Clindesse (clindamycin phosphate) . See the end of this leaflet for a complete list of ingredients in Clindesse (clindamycin phosphate) .
  • have had bowel problems such as:
    • inflammation of your intestines (enteritis)
    • inflammation of your colon (colitis)
    • diarrhea due to a Clostridum difficile infection (CDAD)

Talk to your healthcare provider before using this medicine if you have any of these conditions.

What should I tell my healthcare provider before using Clindesse (clindamycin phosphate) ?

Before you use Clindesse (clindamycin phosphate) , tell your healthcare provider if you:

  • are pregnant or plan to become pregnant. It is not known if Clindesse (clindamycin phosphate) will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Clindesse (clindamycin phosphate) passes into your breast milk. You and your healthcare provider should decide if you will take Clindesse (clindamycin phosphate) or breast feed.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Clindesse (clindamycin phosphate) may affect how other medicines work, and other medicines may affect how Clindesse (clindamycin phosphate) works.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I use Clindesse (clindamycin phosphate) ?

  • Use Clindesse (clindamycin phosphate) exactly as your healthcare provider tells you.
  • Insert Clindesse (clindamycin phosphate) in the vagina one time. See the “Patient Instructions for Use” at the end of this leaflet.
  • Insert all of the Clindesse (clindamycin phosphate) cream into your vagina.
  • Do not use Clindesse (clindamycin phosphate) after the expiration date on the package.
  • Do not get Clindesse (clindamycin phosphate) in your eyes. If you accidently get Clindesse (clindamycin phosphate) in your eyes rinse your eyes with cool tap water right away and call your healthcare provider.

What should I avoid while using Clindesse (clindamycin phosphate) ?

After you insert Clindesse (clindamycin phosphate) you should:

  • not have vaginal intercourse or use of other vaginal products (such as tampons or douches) for at least 7 days.
  • not use barrier contraceptive products for 5 days. Barrier contraceptives include condoms or contraceptive diaphragms used for birth control or to protect yourself against HIV or other sexually transmitted diseases. Clindesse (clindamycin phosphate) contains mineral oil that may weaken latex or rubber products such as condoms or vaginal contraceptive diaphragms.

What are the possible side effects of Clindesse (clindamycin phosphate) ?

Clindesse (clindamycin phosphate) may cause serious side effects, including diarrhea. One type of diarrhea is caused by an infection in your intestines called Clostridium difficile-associated diarrhea (CDAD). If you have diarrhea after you use Clindesse (clindamycin phosphate) , call your healthcare provider.

The most common side effects of Clindesse (clindamycin phosphate) include:

  • fungal infection in your vagina. You may need to take an anti-fungal medicine if you get a fungal infection.
  • headache
  • back pain
  • constipation
  • urinary tract infection

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of Clindesse (clindamycin phosphate) . For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1800-FDA-1088.

How should I store Clindesse (clindamycin phosphate) ?

  • Store Clindesse (clindamycin phosphate) at 68°F to 77°F (20°C to 25°C).
  • Keep Clindesse (clindamycin phosphate) and all medicines out of the reach of children.

General information about the safe and effective use of Clindesse (clindamycin phosphate) .

Medicines are sometimes prescribed for purposes other than those listed in a patient information leaflet. Do not use Clindesse (clindamycin phosphate) for a condition for which it was not prescribed. Do not give Clindesse (clindamycin phosphate) to other people, even if they have the same symptoms you have. It may harm them.

This leaflet summarizes the most important information about Clindesse (clindamycin phosphate) . If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Clindesse (clindamycin phosphate) that is written for health professionals.

For more information, go to www.clindesse (clindamycin phosphate) .com or call 1-877-567-7676.

What are the ingredients in Clindesse?

Active ingredient: clindamycin phosphate

Inactive ingredients: edetate disodium, glycerol monoisostearate, lecithin, methylparaben, microcrystalline wax, mineral oil, polyglyceryl-3-oleate, propylparaben, purified water, silicon dioxide and sorbitol solution

Patient Instructions for Use

(clindamycin phosphate) Vaginal Cream, 2%

For vaginal use only.

Do not put Clindesse (clindamycin phosphate) in your eyes, mouth, or on your skin.

It is important that you read and follow these directions on how to use Clindesse (clindamycin phosphate) vaginal cream properly.

Clindesse (clindamycin phosphate) comes in a single-dose, pre-filled, disposable applicator that gives you a certain amount of clindamycin cream to be inserted into your vagina.

Step 1. Prepare the applicator.

  • Peel back the protective foil and remove the pre-filled applicator. Do not remove the tip. The applicator is made to be used with the tip in place. Do not use the applicator if the tip has been removed (see Figure 1).

Do not use the applicator if the tip has been removed - Illustration

  • Activate the plunger before you use it. To activate the plunger, pull the ring back to fully extend the plunger while you firmly hold the applicator (see Figure 2).

Step 2. Insert the applicator.

Gently insert the applicator into your vagina as far as it will comfortably go (see Figure 3).

Figure 3

Gently insert the applicator - Illustration

Step 3. Apply the cream.

Push the plunger in until all of the cream goes into your vagina (see Figures 4 and 5).

Figure 4 and Figure 5

Push the plunger in until all of the cream goes in - Illustration

Step 4. Remove the empty applicator from your vagina and throw it away in the trash.

Last reviewed on RxList: 11/22/2016
This monograph has been modified to include the generic and brand name in many instances.

Clindesse - User Reviews

Clindesse User Reviews

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Here is a collection of user reviews for the medication Clindesse sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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