February 6, 2016
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Clindets Side Effects Center

Pharmacy Editor: Omudhome Ogbru, PharmD

Clindets (clindamycin) is a topical solution of the antibiotic clindamycin and is used for treating acne. Side effects of Clindets include burning, itching, dryness, redness, and peeling.

A thin film should be applied to affected areas twice daily with a Clindets applicator. It is not known whether clindamycin is excreted in human milk following use of Clindets. Clindets has not been adequately evaluated in pregnant women. Clindets should be used during pregnancy only if it is clearly needed. Since oral and intravenous clindamycin appear in breast milk nursing women should decide whether to stop breast feeding or discontinue Clindets.

Our Clindets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Clindets FDA Prescribing Information: Side Effects
(Adverse Reactions)


In 18 clinical studies of various topical formulations of clindamycin phosphate using placebo vehicle and/or active comparator drugs as controls, patients experienced a number of treatment emergent adverse dermatological events (see table below).


Number of patients reporting events
Treatment Emergent
Adverse Event
n=553 (%)
n=148 (%)
n=160 (%)
62 (11)
15 (10)
17 (11)
36 (7)
15 (10)
17 (11)
60 (11)
# (-)
# (-)
105 (19)
34 (23)
29 (18)
86 (16)
10 (7)
22 (14)
Oiliness/Oily Skin
8 (1)
26 (18)
12 * (10)
61 (11)
# (-)
11 (7)
# not recorded     
* of 126 subjects

Read the entire FDA prescribing information for Clindets (Clindamycin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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