Clinoril (Sulindac) Drug Information: Overdosage and Contraindications

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May 26, 2012

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Ankylosing Spondylitis »

Ankylosing spondylitis facts

Ankylosing spondylitis belongs to a group of arthritis conditions which tend to cause chronic inflammation of the spine (spondyloarthropathies).
Ankylosing spondylitis affects males two to three times more commonly than females.
Ankylosing spondylitis is a cause of back pain in adolescents and young adults.
The tendency to develop ankylosing spondylitis is genetically inherited.
The HLA-B27 gene can be detected in the blood of most patients with ankylosing spondylitis.
Ankylosing spondylitis can also affect the eyes, heart, lungs, and occasionally the kidneys.
The optimal treatment of ankylosing spondylitis involves medications that reduce inflammation or suppress immunity, physical therapy, and exercise.

What is ankylosing spondylitis?

Ankylosing spondylitis is a form of chronic inflammat...

Read the Ankylosing Spondylitis article »

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OVERDOSE

Management Of Overdosage

Cases of overdosage have been reported and rarely, deaths have occurred. The following signs and symptoms may be observed following overdosage: stupor, coma, diminished urine output and hypotension.

In the event of overdosage, the stomach should be emptied by inducing vomiting or by gastric lavage, and the patient carefully observed and given symptomatic and supportive treatment.

Animal studies show that absorption is decreased by the prompt administration of activated charcoal and excretion is enhanced by alkalinization of the urine.

CONTRAINDICATIONS

CLINORIL (sulindac) is contraindicated in patients with known hypersensitivity to sulindac or the excipients (see DESCRIPTION).

CLINORIL (sulindac) should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic/anaphylactoid reactions to NSAIDs have been reported in such patients (see WARNINGS – Anaphylactic/Anaphylactoid Reactions, and PRECAUTIONS – Preexisting Asthma).

CLINORIL (sulindac) is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Last reviewed on RxList: 7/1/2010
This monograph has been modified to include the generic and brand name in many instances.