Clobevate (Clobetasol Propionate Gel) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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Clobevate

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Clobevate®
(clobetasol propionate) Gel 0.05%*

*potency expressed as clobetasol propionate

FOR TOPICAL DERMATOLOGIC USE ONLY-NOT FOR OPHTHALMIC, ORAL, OR INTRAVAGINAL USE

DRUG DESCRIPTION

Clobevate® (Clobetasol Propionate Gel) contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.

Chemically, clobetasol propionate is 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate, and it has the following structural formula:

Clobevate® (Clobetasol Propionate) structural formula illustration

Clobetasol propionate has the molecular formula C₂₅H₃₂C_lFO₅ and a molecular weight of 466.98. It is a white to cream-colored crystalline powder insoluble in water.

Each gram, for topical administration, contains clobetasol propionate 0.5 mg in a base of propylene glycol, carbomer 934P, sodium hydroxide, and purified water.

What are the possible side effects of clobetasol topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as: