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Clobevate® (Clobetasol Propionate Gel) contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.

Chemically, clobetasol propionate is 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate, and it has the following structural formula:

Clobetasol propionate has the molecular formula C₂₅H₃₂C_lFO₅ and a molecular weight of 466.98. It is a white to cream-colored crystalline powder insoluble in water.

Each gram, for topical administration, contains clobetasol propionate 0.5 mg in a base of propylene glycol, carbomer 934P, sodium hydroxide, and purified water.

Last reviewed on RxList: 5/5/2009
This monograph has been modified to include the generic and brand name in many instances.