CLOBEX® (clobetasol propionate) Lotion, 0.05% contains clobetasol propionate,
a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids
constitute a class of primarily synthetic steroids used topically as anti-inflammatory
and antipruritic agents. Clobetasol propionate is 21-chloro-9-fluoro-11β,17-dihydroxy-16β
-methylpregna-1,4-diene-3, 20-dione17-propionate, with the empirical formula
C25H32CIFO5, a molecular weight of 466.98 (CAS
Registry Number 25122-46-7).O
The following is the chemical structure:
Clobetasol propionate is a white to practically-white crystalline powder insoluble
in water.
Each gram of CLOBEX® (clobetasol propionate) Lotion, 0.05% contains 0.5
mg of clobetasol propionate, in a vehicle base composed of hypromellose, propylene
glycol, mineral oil, polyoxyethylene glycol 300 isostearate, carbomer 1342,
sodium hydroxide and purified water.
What are the possible side effects of clobetasol topical?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as:
- blurred vision, or seeing halos around lights;
- mood changes;
- sleep problems (insomnia);
- weight gain, puffiness in your face; or
- muscle...
Read All Potential Side Effects and See Pictures of Clobex Lotion »
Last reviewed on RxList: 12/1/2008
This monograph has been modified to include the generic and brand name in many instances.