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Clobex Lotion

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Clobex Lotion

(clobetasol propionate) Lotion, 0.05%

For dermatologic use only
Not for ophthalmic, oral or intravaginal use


CLOBEX® (clobetasol propionate) Lotion, 0.05% contains clobetasol propionate, a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.

Clobetasol propionate is 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4diene-3, 20-dione 17-propionate, with the empirical formula C25H32CIFO5, a molecular weight of 466.98 (CAS Registry Number 25122-46-7).

The following is the chemical structure:

CLOBEX® (clobetasol propionate) Structural Formula Illustration

Clobetasol propionate is a white to practically-white crystalline powder insoluble in water.

Each gram of CLOBEX® (clobetasol propionate) Lotion, 0.05% contains 0.5 mg of clobetasol propionate, in a vehicle base composed of hypromellose, propylene glycol, mineral oil, polyoxyethylene glycol 300 isostearate, carbomer 1342, sodium hydroxide and purified water.

What are the possible side effects of clobetasol topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when clobetasol topical is applied to the skin, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream.

Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as:

  • blurred vision, or...

Read All Potential Side Effects and See Pictures of Clobex Lotion »

Last reviewed on RxList: 8/30/2012
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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