CLOBEX® (clobetasol propionate) Lotion, 0.05% contains clobetasol propionate,
a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids
constitute a class of primarily synthetic steroids used topically as anti-inflammatory
and antipruritic agents. Clobetasol propionate is 21-chloro-9-fluoro-11β,17-dihydroxy-16β
-methylpregna-1,4-diene-3, 20-dione17-propionate, with the empirical formula
C25H32CIFO5, a molecular weight of 466.98 (CAS
Registry Number 25122-46-7).O
The following is the chemical structure:
Clobetasol propionate is a white to practically-white crystalline powder insoluble
in water.
Each gram of CLOBEX® (clobetasol propionate) Lotion, 0.05% contains 0.5
mg of clobetasol propionate, in a vehicle base composed of hypromellose, propylene
glycol, mineral oil, polyoxyethylene glycol 300 isostearate, carbomer 1342,
sodium hydroxide and purified water.
Last reviewed on RxList: 12/1/2008
This monograph has been modified to include the generic and brand name in many instances.