Clobex Shampoo

Clobex® Shampoo
(clobetasol propionate) Shampoo, 0.05%

For External Use Only. Not for Ophthalmic Use.

DRUG DESCRIPTION

CLOBEX® (clobetasol propionate) Shampoo, 0.05%, contains clobetasol propionate, a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.

The chemical name of clobetasol propionate is 21-chloro-9-fluoro-11β,17-dihydroxy-16β -methylpregna-1, 4-diene-3, 20-dione 17-propionate.

It has the following structural formula:

CLOBEX® (clobetasol propionate)  structural formula illustration

Clobetasol propionate has a molecular weight of 466.97 (CAS Registry Number 25122-46-7). The molecular formula is C25H32CIFO5. Clobetasol propionate is a white to practically white crystalline, odorless powder insoluble in water.

Each mL of CLOBEX® (clobetasol propionate) Shampoo,0.05%, contains clobetasol propionate, 0.05%, in a shampoo base consisting of alcohol, citric acid, coco-betaine, polyquaternium-10, purified water, sodium citrate, and sodium laureth sulfate.

What are the possible side effects of clobetasol topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when clobetasol topical is applied to the skin, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream.

Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as:

  • blurred vision, or...

Read All Potential Side Effects and See Pictures of Clobex Shampoo »

Last reviewed on RxList: 12/1/2008
This monograph has been modified to include the generic and brand name in many instances.

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