"The US Food and Drug Administration (FDA) has approved a foam containing calcipotriene and betamethasone dipropionate (Enstilar, Leo Pharma Inc) for topical treatment of plaque psoriasis in adults 18 years of age and older, according to a "...
Clobex Shampoo Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Clobex (clobetasol propionate) Shampoo is a topical (for the skin) steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Clobex Shampoo is available in generic form. Common side effects of Clobex Shampoo include mild skin rash, itching, burning, or redness, dry or cracking skin, thinning or softening of the skin, skin rash or irritation around the mouth, swollen hair follicles, temporary hair loss, spider veins, changes in color of treated skin, blisters, pimples, crusting of treated skin, or stretch marks.
The recommended dose of Clobex Shampoo is to apply onto dry (not wet) scalp once a day in a thin film to the affected areas only, and left in place for 15 minutes before lathering and rinsing. It is not likely other drugs you take orally or inject will have an effect on topically applied Clobex. But many drugs can interact with each other. Tell your doctor all medications and supplements you use. During pregnancy, Clobex should be used only if prescribed. It may be harmful to a fetus. It is unknown if this medication passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.
Our Clobex (clobetasol propionate) Shampoo Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Clobex Shampoo in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Although the risk of serious side effects is low when clobetasol topical is applied to the skin, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream.
Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as:
- blurred vision, or seeing halos around lights;
- mood changes;
- sleep problems (insomnia);
- weight gain, puffiness in your face; or
- muscle weakness, feeling tired.
Less serious side effects may include:
- mild skin rash, itching, burning, or redness;
- dry or cracking skin;
- thinning or softening of your skin;
- skin rash or irritation around your mouth;
- swollen hair follicles;
- temporary hair loss;
- spider veins;
- changes in color of treated skin;
- blisters, pimples, or crusting of treated skin; or
- stretch marks.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Clobex Shampoo (Clobetasol Propionate Shampoo)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Clobex Shampoo FDA Prescribing Information: Side Effects
In clinical trials with CLOBEX® Shampoo (clobetasol propionate shampoo) , the following adverse reactions have been reported: burning/stinging, pruritus, edema, folliculitis, acne, dry skin, irritant dermatitis, alopecia, urticaria, skin atrophy and telangiectasia.
The table below summarizes selected adverse events that occurred in at least 1% of subjects in the Phase 2 and 3 studies for scalp psoriasis.
Summary of Selected Adverse Events ≥ 1% by
|Skin and Appendages||49 (8.8%)||28 (22.0%)|
|Discomfort Skin||26 (4.7%)||16 (12.6%)|
|Pruritus||3 (0.5%)||9 (7.1%)|
|Body As A Whole||33 (5.9%)||12 (9.4%)|
|Headache||10 (1.8%)||1 (0.8%)|
The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximately decreasing order of occurrence: hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, and miliaria.
Read the entire FDA prescribing information for Clobex Shampoo (Clobetasol Propionate Shampoo)
Additional Clobex Shampoo Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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