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Clolar

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Clolar

Clolar

PATIENT INFORMATION

Hematologic Toxicity

Advise patients to return for regular blood counts and to report any symptoms associated with hematologic toxicity (such as weakness, fatigue, pallor, shortness of breath, easy bruising, petechiae, purpura, fever) to their physician [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS].

Infection

Advise patients of the signs or symptoms of infection (e.g., fever) and report to the physician immediately if any occur [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS].

Hepatic and Renal Toxicity

Advise patients to avoid medications including over the counter and herbal medications, which may be hepatotoxic or nephrotoxic, during the 5 days of Clolar administration. Also, advise patients of the possibility of developing liver function abnormalities and to immediately report signs or symptoms of jaundice [see WARNINGS AND PRECAUTIONS].

Systemic Inflammatory Response Syndrome (SIRS)/Capillary Leak Syndrome

Advise patients of the signs or symptoms of SIRS, such as fever, tachycardia, tachypnea, dyspnea and symptoms suggestive of hypotension [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS].

Pregnancy and Breast-feeding

Advise male and female patients with reproductive potential to use effective contraceptive measures to prevent pregnancy [see WARNINGS AND PRECAUTIONS, Use in Specific Populations]. Advise female patients to avoid breast- feeding during Clolar treatment [see Use In Specific Populations].

Gastrointestinal Disorders

Advise patients that they may experience nausea,vomiting, and/or diarrhea with Clolar. If these symptoms are significant, they should seek medical attention.

Rash

Advise patients that they may experience skin rash with Clolar. If this symptom is significant, they should seek medical attention.

Last reviewed on RxList: 2/1/2013
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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