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Clolar Patient Information Including Side Effects

Brand Names: Clolar

Generic Name: clofarabine (Pronunciation: kloe FAR a been)

What is clofarabine (Clolar)?

Clofarabine is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Clofarabine is used to treat acute lymphoblastic leukemia (a type of blood cancer) in children and young adults up to 21 years old.

Clofarabine is usually given after other cancer medicines have been tried without successful treatment.

Clofarabine may also be used for purposes not listed in this medication guide.

What are the possible side effects of clofarabine (Clolar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • runny or stuffy nose, cough, rapid breathing and heart rate, trouble breathing, swelling and pain in any part of your body;
  • lower back pain, blood in your urine, urinating less than usual or not at all;
  • numbness or tingly feeling around your mouth;
  • muscle weakness, tightness, or contraction, overactive reflexes;
  • fast or slow heart rate, weak pulse, feeling short of breath, confusion, fainting;
  • numbness or redness on the palms of your hands or the soles of your feet;
  • jaundice (yellowing of the skin or eyes); or
  • signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), purple or red pinpoint spots under your skin, loss of appetite, mouth sores, unusual weakness.

Less serious side effects may include:

  • nausea, vomiting, stomach pain;
  • diarrhea, rectal pain;
  • headache, muscle or joint pain;
  • mild itching or skin rash;
  • feeling tired, anxious, irritable; or
  • warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Clolar (clofarabine) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about clofarabine (Clolar)?

Do not use clofarabine if you are pregnant. It could harm the unborn baby.

Use birth control to prevent pregnancy while you are receiving clofarabine, whether you are a man or a woman. Clofarabine use by either parent may cause birth defects.

If you have liver or kidney disease, you may need a dose adjustment or special tests to safely receive clofarabine.

To be sure this medication is not causing harmful effects, your blood cells, kidney function, and liver function may need to be tested often. Visit your doctor regularly.

Clofarabine can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Avoid being near people who are sick or have infections. Contact your doctor at once if you develop signs of infection.

Clofarabine can harm your liver or kidneys. This effect is increased when you also use other medicines harmful to the liver or kidneys. During your 5-day treatment with clofarabine, you may need to avoid using certain medications, including some over-the-counter medicines. Tell your doctor about all other medicines you use.

Tell your caregivers at once if you have a serious side effect such as rapid breathing and heart rate, trouble breathing, painful swelling, numbness or tingling, feeling like you might pass out, lower back pain, blood in your urine, urinating less than usual, or jaundice (yellowing of the skin or eyes).

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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