April 29, 2017
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Clonazepam

Medical and Pharmacy Editor:

Brand Name: Klonopin

Generic Name: clonazepam

Drug Class: Anticonvulsants, Other; Anti-anxiety Agents; Anxiolytics, Benzodiazepines

What Is Clonazepam and How Does It Work?

Clonazepam (Klonopin) is a prescription drug that is used to as a treatment to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug, which is used in the treatment of epileptic seizures. This drug is also used as a treatment for panic attacks, insomnia, and symptoms related to chronic anxiety and anxiety disorders. Clonazepam works by calming your brain and nerves.

It belongs to a class of drugs called benzodiazepines.

Benzodiazepines, also called "benzos' or BZs" for short, are a class of medications that work by affecting neurotransmitters in the brain. Neurotransmitters are chemicals that nerves release in order to communicate with other nearby nerves. Common generic and brand names for benzodiazepines are:

This medication is by prescription only.

Consumers of this drug should read the information leaflet that accompanies the prescription each and every time it is filled. There may be new or different health information.

Risk of abuse or misuse of this medication is very high. This drug poses dependence, withdrawal symptoms and other long-term effects.

Clonazepam is available under the following different brand names: Klonopin.

Dosages:

Dosage Forms and Strengths

Tablet dispersible: Schedule IV

  • 0.12 mg
  • 0.25 mg
  • 0.5 mg
  • 1 mg
  • 2 mg

Tablet: Schedule IV (Adult Only)

  • 0.5 mg
  • 1 mg
  • 2 mg

Dosage Considerations – Should be Given as Follows:

Panic Disorder Treatment

  • Dose 0.25 mg orally every 12 hours initially; may increase to 1 mg/day after 3 days (may increase up to 4 mg/day in some patients)

Treatment of Seizure Disorders

  • Seizures in adults: 1.5 mg/day orally divided every 8 hours; increase by 0.5-1 mg every 3 days until desired effect achieved; not to exceed 20 mg/day
  • Maintenance for seizures in adults: 2-8 mg orally; not to exceed 20 mg/day
  • Children younger than 6 years:
    • Potential toxic dose: 0.05 mg/kg
  • Children younger than 10 years or less than 30 kg
    • Dose 0.01-0.03 mg/kg/day orally divided every 8 hours; increase by 0.25-0.5 mg/day every 3 days to maximum 0.1-0.2 mg/kg/day orally divided every 8 hours
    • Maintenance dose: 0.1-0.2 mg per kg per day orally divided every 8 hours; not to exceed 0.2 mg per kg per day
  • Children younger than 10 years or more than 30 kg
    • 1.5 mg/day orally divided every 8 hours; increase by 0.5-1 mg every 3 days until desired effect achieved; not to exceed 20 mg/day
    • Maintenance: 2-8 mg orally; not to exceed 20 mg/day

Dosing Considerations

  • Discontinuation of treatment (seizures in adults): Withdraw treatment gradually over time; decrease the dose once every 3 days by 0.125 mg orally every 12 hours until completely withdrawn
  • Discontinuation of treatment (seizures in children)
    • Children younger than 10 years: Treatment should be withdrawn gradually over time, as necessary
    • Children older than 10 years: Withdraw treatment gradually over time; decrease the dose every 3 days by 0.125 mg orally every 12 hours until completely withdrawn

Dosing Modifications

  • Renal impairment: Supplemental dose in hemodialysis not necessary
Medically Reviewed by a Doctor on 4/25/2017



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