Clorpres (Clonidine Hydrochloride and Chlorthalidone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Clorpres

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CLORPRES
(clonidine hydrochloride and chlorthalidone) Tablet 0.1 mg/15 mg, 0.2 mg/15 mg
and 0.3 mg/15 mg

DRUG DESCRIPTION

CLORPRES (clonidine hydrochloride and chlorthalidone) ® is a combination of clonidine hydrochloride (a centrally acting antihypertensive agent) and chlorthalidone (a diuretic).

CLORPRES (clonidine hydrochloride and chlorthalidone) ® is available as tablets for oral administration in three dosage strengths: 0.1 mg/15 mg, 0.2 mg/15 mg and 0.3 mg/15 mg of clonidine hydrochloride/chlorthalidone, respectively.

The inactive ingredients are ammonium chloride, colloidal silicon dioxide, croscarmellose sodium (Type A), magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, D&C yellow #10.

Clonidine Hydrochloride

Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. The chemical name is 2-[(2,6-dichlorophenyl)imino]imidazoline monohydrochloride. The following are the structural formula, molecular formula and molecular weight:

Clonidine hydrochloride is an odorless, bitter, white crystalline substance soluble in water and alcohol.

Chlorthalidon

Chlorthalidone is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double ring system is incorporated in its structure. It is 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl) benzenesulfonamide with the following structural formula, molecular formula and molecular weight:

Chlorthalidone is practically insoluble in water, in ether and in chloroform; soluble in methanol; slightly soluble in alcohol.

What are the possible side effects of clonidine and chlorthalidone (Clorpres)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

dry mouth, increased thirst, drowsiness, restless feeling, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions);
easy bruising or bleeding, unusual weakness;
red or purple spots...

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What are the precautions when taking clonidine hydrochloride and chlorthalidone (Clorpres)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to clonidine or chlorthalidone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease (inability to make urine).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, blood circulation problem (e.g., Raynaud's disease, stroke), depression, gout, heart disease (e.g., irregular heartbeat, recent heart attack, chest pain, heart failure), kidney disease,...

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Last reviewed on RxList: 8/27/2009
This monograph has been modified to include the generic and brand name in many instances.