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Clorpres Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Clorpres (clonidine hydrochloride and chlorthalidone) is a combination of an antihypertensive (lowers blood pressure) and a thiazide diuretic (water pill) used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. Clorpres is also used to treat high blood pressure (hypertension). Common side effects of Clorpres include dizziness, drowsiness, dry mouth, headache, constipation, diarrhea, upset stomach, weakness, tiredness, loss of appetite, restlessness, nervousness, sleep problems (insomnia), nightmares or unusual dreams, breast swelling or tenderness, itching or skin rash, impotence, loss of interest in sex, or increased urination as your body adjusts to the medication.
One Clorpres tablet administered once or twice daily can be used to administer a minimum dose of 0.1 mg clonidine hydrochloride and 15 mg chlorthalidone to a maximum dose of 0.6 mg clonidine hydrochloride and 30 mg chlorthalidone. Clorpres may interact with other blood pressure medications, lithium, digitalis, insulin or oral diabetes medicines, or antidepressants. Tell your doctor all medications and supplements you use. During pregnancy, Clorpres should be used only when prescribed. This drug passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.
Our Clorpres (clonidine hydrochloride and chlorthalidone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Clorpres in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- dry mouth, increased thirst, drowsiness, restless feeling, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions);
- easy bruising or bleeding, unusual weakness;
- red or purple spots on your skin;
- confusion, hallucinations;
- urinating more or less than usual, or not at all;
- feeling short of breath, even with mild exertion;
- swelling, rapid weight gain;
- numbness or tingly feeling; or
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- dry mouth, loss of appetite;
- diarrhea, constipation, upset stomach;
- dizziness, drowsiness;
- feeling restless or nervous;
- sleep problems (insomnia);
- nightmares or unusual dreams;
- breast swelling or tenderness;
- mild itching or skin rash; or
- impotence or loss of interest in sex.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Clorpres (Clonidine Hydrochloride and Chlorthalidone)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Clorpres FDA Prescribing Information: Side Effects
CLORPRES (clonidine hydrochloride and chlorthalidone) ® is generally well tolerated. Most adverse effects are mild and tend to diminish with continued therapy. The most frequent (which appear to be dose-related) are dry mouth, occurring in about 40 of 100 patients; drowsiness, about 33 in 100; dizziness, about 16 in 100; constipation and sedation, each about 10 in 100. In addition to the reactions listed above, certain less frequent adverse experiences, which are shown below, have also been reported
in patients receiving the component drugs of CLORPRES (clonidine hydrochloride and chlorthalidone) ® but in many cases patients were receiving concomitant medication and a causal relationship has not been established:
Gastrointestinal:Nausea and vomiting, about 5 in 100 patients; anorexia and malaise, each about 1 in 100; mild transient abnormalities in liver function tests, about 1 in 100; rare reports of hepatitis; parotitis, rarely.
Metabolic: Weight gain, about 1 in 100 patients; gynecomastia, about 1 in 1000, transient elevation of blood glucose or serum creatine phosphokinase, rarely.
Central Nervous System: Nervousness and agitation, about 3 in 100 patients; mental depression, about 1 in 100; headache, about 1 in 100; insomnia, about 5 in 1000. Vivid dreams or nightmares, other behavioral changes, restlessness, anxiety, visual and auditory hallucinations and delirium have been reported.
Cardiovascular: Orthostatic symptoms, about 3 in 100 patients; palpitations and tachycardia, and bradycardia, each about 5 in 1000. Raynaud's phenomenon, congestive heart failure, and electrocardiographic abnormalities, i.e., conduction disturbances and arrhythmias, have been reported rarely. Rare cases of sinus bradycardia and atrioventricular block have been reported, both with and without the use of concomitant digitalis.
Genitourinary: Decreased sexual activity, impotence and loss of libido, about 3 in 100 patients; nocturia, about 1 in 100; difficulty in micturition, about 2 in 1000; urinary retention, about 1 in 1000.
Other: Weakness, about 10 in 100 patients; fatigue, about 4 in 100; discontinuation syndrome, about 1 in 100; muscle or joint pain, about 6 in 1000 and cramps of the lower limbs, about 3 in 1000. Dryness, burning of the eyes, blurred vision, dryness of the nasal mucosa, pallor, weakly positive Coombs' test, increased sensitivity to alcohol and fever have been reported.
Cardiovascular: Orthostatic hypotension may occur and may be aggravated by alcohol, barbiturates or narcotics.
Whenever adverse reactions are moderate or severe, chlorthalidone dosage should be reduced or therapy withdrawn.
Read the entire FDA prescribing information for Clorpres (Clonidine Hydrochloride and Chlorthalidone)
Additional Clorpres Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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