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Clozaril

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Clozaril

Overdosage
Contraindications

OVERDOSE

Overdosage Experience

The most commonly reported signs and symptoms associated with clozapine overdose are: sedation, delirium, coma, tachycardia, hypotension, respiratory depression or failure; and hypersalivation. There are reports of aspiration pneumonia, cardiac arrhythmias, and seizure. Fatal overdoses have been reported with clozapine, generally at doses above 2500 mg. There have also been reports of patients recovering from overdoses well in excess of 4 g.

Management of Overdosage

For the most up-to-date information on the management of CLOZARIL overdosage, contact a certified Regional Poison Control Center (1-800-222-1222). Telephone numbers of certified Regional Poison Control Centers are listed in the Physicians' Desk Reference®, a registered trademark of Thomson PDR. Establish and maintain an airway; ensure adequate oxygenation and ventilation. Monitor cardiac status and vital signs. Use general symptomatic and supportive measures. There are no specific antidotes for CLOZARIL.

In managing overdosage, consider the possibility of multiple-drug involvement.

CONTRAINDICATIONS

History of Clozapine-induced Agranulocytosis or Severe Granulocytopenia

CLOZARIL is contraindicated in patients with a history of clozapine-induced agranulocytosis or severe granulocytopenia [see WARNINGS AND PRECAUTIONS].

Hypersensitivity

CLOZARIL is contraindicated in patients with a history of hypersensitivity to clozapine (e.g., photosensitivity, vasculitis, erythema multiforme, or Stevens-Johnson Syndrome) or any other component of CLOZARIL [see ADVERSE REACTIONS].

Last reviewed on RxList: 8/2/2013
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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Clozaril - User Reviews

Clozaril User Reviews

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